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Randomized, Triple-Blind, and Parallel-Controlled Trial of Transcranial Direct Current Stimulation for Cognitive Rehabilitation after Stroke
Published on: June 6, 2025
Pragmatic multicenter randomized controlled study on early supported discharge after stroke in Korea: the KOMPACT
Won Kee Chang1, Yun-Sun Jung1, Ji-Soo Choi1
1Department of Rehabilitation Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea.
Early supported discharge (ESD) in Korea showed comparable clinical and economic outcomes to conventional rehabilitation for stroke patients. ESD improved mood and patient satisfaction, suggesting its feasibility as a transitional care model.
Area of Science:
- Neurology
- Rehabilitation Medicine
- Health Services Research
Background:
- Early supported discharge (ESD) is beneficial in Western stroke care but its effectiveness in Asian healthcare systems is not well-established.
- This study evaluates ESD in the Korean context for post-acute stroke recovery.
Purpose of the Study:
- To compare the efficacy and economic impact of ESD versus conventional rehabilitation (CR) in Korean acute stroke patients.
- To assess functional outcomes, mood, costs, and patient satisfaction.
Main Methods:
- The Korean Model for post-acute comprehensive rehabilitation (KOMPACT) study was a multicenter, randomized controlled trial.
- Patients with mild-to-moderate stroke (mRS 1-3) were assigned to ESD (home-based rehab, liaison services) or CR.
- Outcomes were assessed at baseline, 1 month, and 3 months post-stroke.
Main Results:
- No significant differences in clinical outcomes or functional dependence between ESD and CR groups.
- The ESD group showed significantly greater improvement in depressive symptoms (p=0.025).
- Patient and caregiver satisfaction were higher in the ESD group; length of stay and total costs were comparable.
Conclusions:
- ESD is a feasible transitional care model for Korean stroke patients, offering comparable clinical and economic outcomes to CR.
- ESD demonstrated potential benefits in mood improvement and higher patient satisfaction.
- Further research with larger samples and longer follow-up is recommended to confirm long-term effects.
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