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Preclinical Cardiac Electrophysiology Assessment by Dual Voltage and Calcium Optical Mapping of Human Organotypic Cardiac Slices
Published on: June 16, 2020
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Recovering intrinsic conduction velocity and action potential duration from electroanatomic mapping data using
Caroline Roney1, Gernot Plank2, Shohreh Honarbakhsh3
1School of Engineering and Materials Science, Queen Mary University of London, Mile End Road, E1 4NS, London, England, United Kingdom.
Medical Image Analysis
|September 19, 2025
Summary
Wavefront curvature significantly impacts cardiac electrical propagation, affecting conduction velocity and action potential duration. Understanding this relationship helps recover intrinsic tissue properties and identify slow conduction zones.
Area of Science:
- Cardiac Electrophysiology
- Computational Biology
- Biophysics
Background:
- Electroanatomic mapping systems assess cardiac electrical activity.
- Cardiac tissue architecture creates anisotropic conductivity and complex wavefronts.
- Wavefront curvature influences conduction velocity (CV) and action potential duration (APD).
Purpose of the Study:
- To quantify the impact of wavefront curvature and conductivity on CV and APD.
- To recover intrinsic cardiac tissue properties.
- To investigate the role of geometric curvature versus fiber structure in propagation.
Main Methods:
- Simulations using multiple ionic models with varying wavefront curvatures (positive and negative).
- Verification in realistic 2D and 3D cardiac tissue models.
- Analysis of clinical electroanatomic mapping data.
Main Results:
- CV and APD changes due to curvature are described by simple formulas.
- Intrinsic propagation velocities can be recovered when fiber structure is known.
- Ignoring fiber structure leads to spurious high curvature regions, crucial for identifying slow conduction.
Conclusions:
- Wavefront curvature is a key factor influencing cardiac electrical propagation.
- Accurate recovery of intrinsic tissue properties requires considering fiber structure alongside curvature.
- This research aids in identifying pathological zones of slow conduction.
