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Danger zone: The balance between fat-driven health and death
Jenny Jin1, Liam N Stiles1, Brent R Stockwell2
1Department of Biological Sciences, Columbia University, New York, NY 10027, USA.
Molecular Cell
|September 19, 2025
Abstract
None:
Damage to polyunsaturated fats causes ferroptotic cell death. In this issue, Deng et al.1 show that the incorporation of the fatty acid DHA into membranes is controlled by the protein UBXD8, as a natural mechanism to prevent overloading cells with dangerous fat, preventing ferroptosis.
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