Related Experiment Video
Updated: Jan 17, 2026
10:39
3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
Published on: June 2, 2014
18.7K
Migraine: advances in treatment.
Usman Ashraf1, Peter J Goadsby2
1NIHR King's Clinical Research Facility, SLaM Biomedical Research Centre, King's College London, London, UK; Wolfson Sensory, Pain and Regeneration Centre, King's College London, London, UK.
Trends in Molecular Medicine
|September 19, 2025
Summary
New migraine treatments target calcitonin gene-related peptide and serotonin 5HT1F receptors. Research explores novel therapies for non-responders, aiming for precision migraine management.
Area of Science:
- Neurology
- Pharmacology
Background:
- Migraine pathophysiology understanding has driven new drug development.
- Calcitonin gene-related peptide (CGRP) and its receptor are key targets.
- Serotonin 5HT1F receptor agonists (ditans) offer acute migraine management, bypassing risks of 5HT1B/1D agonists (triptans).
Purpose of the Study:
- To review current and emerging therapies for migraine.
- To highlight limitations of existing treatments and unmet needs.
- To discuss the potential for precision medicine in migraine.
Main Methods:
- Literature review of pathophysiology and therapeutic targets in migraine.
- Analysis of efficacy and safety data for CGRP and ditan therapies.
- Exploration of novel and emerging therapeutic targets.
Main Results:
- CGRP-targeting therapies and ditans show efficacy in acute migraine.
- A significant portion of patients do not respond to current therapies.
- Emerging targets include pituitary adenylate cyclase activating polypeptide, amylin, adrenomedullin, KATP channels, transient receptor potential ion channels, and neuronal nitric oxide synthase.
Conclusions:
- Despite advances, many patients remain refractory to current migraine treatments.
- Emerging therapies offer new hope for managing difficult-to-treat migraines.
- Understanding patient heterogeneity is crucial for developing personalized migraine management strategies.
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