Indium-111-labeled autologous leukocytes in man

Area of Science:

• Nuclear Medicine
• Immunology

Background:

• Inflammatory diseases require accurate diagnostic tools.
• Autologous leukocyte labeling offers a potential imaging modality.

Purpose of the Study:

• To evaluate the in vivo kinetics and distribution of indium-111 labeled autologous leukocytes.
• To assess the utility of this method in diagnosing inflammatory conditions.

Main Methods:

• Isolation and labeling of autologous leukocytes with indium-111.
• Administration to 15 patients with suspected inflammatory disease.
• Monitoring of radioactivity distribution and kinetics over 48 hours.

Main Results:

• Indium-111 labeled leukocytes demonstrated stable labeling and predictable biodistribution.
• Initial lung uptake followed by distribution to spleen, liver, and bone marrow.
• Focal accumulation detected in 12/15 patients, correlating with confirmed sepsis; abscess samples showed high radioactivity.

Conclusions:

• Indium-111 labeled autologous leukocytes are a viable tool for detecting inflammatory foci.
• This method shows high sensitivity for identifying sepsis and abscesses.
• Cellular preparation techniques influence cell distribution and diagnostic accuracy.