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A Research Method For Detecting Transient Myocardial Ischemia In Patients With Suspected Acute Coronary Syndrome Using Continuous ST-segment Analysis
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Associations of myocardial bridge with ECG changes and arrhythmia risk in high-risk populations: Systematic review

Hussein Nafakhi1, Yasir Salah Alam1, Alaa Salah Jumaah2

  • 1Department of Internal medicine / Faculty of Medicine, University of Kufa, Kufa, P.O. Box 21, Iraq.

Journal of Electrocardiology
|September 20, 2025
PubMed

Insights

Myocardial bridging (MB) is linked to ventricular arrhythmias and ST-segment changes, especially in high-risk patients. These findings highlight the importance of considering MB in specific clinical contexts for better patient outcomes.

Area of Science:

  • Cardiology
  • Clinical Electrophysiology

Background:

  • Myocardial bridging (MB) is a congenital anomaly where a segment of a coronary artery travels intramyurally.
  • The clinical significance of MB, particularly its association with electrocardiogram (ECG) changes and arrhythmias, remains an area of active research.

Purpose of the Study:

  • To evaluate the relationship between myocardial bridging (MB) and ECG abnormalities.
  • To assess the association of MB with specific arrhythmias, including atrial fibrillation (AF) and ventricular tachycardia/fibrillation (VT/VF).

Main Methods:

  • A comprehensive literature search was performed across major databases (PubMed Central, Scopus, EMBASE) up to November 2024.
  • Included studies focused on MB and its association with ECG changes and arrhythmias in various clinical settings.
  • Meta-analyses were conducted on data from eligible studies, focusing on high-risk populations like those with coronary artery disease (CAD) and hypertrophic cardiomyopathy (HCM).

Main Results:

  • The meta-analysis included 20 studies with 26,932 participants, of whom 12,152 had MB.
  • MB showed a significant association with ST-segment changes (OR 3.467) and VT/VF (OR 3.166).
  • No significant association was found between MB and AF (OR 1.170) or ECG repolarization abnormalities (OR 1.538).
  • In patients with HCM, MB was associated with a higher risk of VT/VF (OR 4.662).

Conclusions:

  • Myocardial bridging is significantly associated with ventricular arrhythmias and ST-segment changes.
  • These associations are particularly pronounced in high-risk populations such as those with HCM.
  • The findings may not be generalizable to the general population or asymptomatic individuals with MB.
Abstract

Keywords:
ArrhythmiaECGMeta-analysisMyocardial bridge

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