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Updated: Jan 17, 2026

Multidisciplinary Approach to Obesity Management: A Case Report
Published on: May 30, 2025
New directions in childhood obesity treatment - A path forward or wishful thinking?
Jessica L Reilly1, Shruthi Arora2, Kelsey Chatman1
1Division of Gastroenterology, Department of Pediatrics, Emory University School of Medicine (Drs Reilly, Chatman), Atlanta, Georgia, USA; Children's Healthcare of Atlanta (Dr Reilly, Arora, Chatman, Cooper, and Hsia), Atlanta, Georgia, USA.
Background:
The advent of highly effective pharmacotherapy that induces significant weight loss has revolutionized the treatment of obesity. Since 2020, these medications have been approved for use in children with obesity 12 years of age and older, and the American Academy of Pediatrics 2023 Clinical Practice Guidelines have endorsed their use.
Sources Of Material:
Specifically, glucagon-like peptide 1 (GLP-1) agonists and similar related nutrient stimulated hormones induce weight loss of >15% of baseline body weight in clinical trials.
Abstract Of Findings:
However, these benefits must be balanced with the known side effects and other potential unknown effects especially in growing children and adolescents. Moreover, barriers to access and long-term effects of these medications need to be addressed.
Conclusion:
In this review, we discuss important considerations for the utilization of these newer weight loss agents in the rapidly evolving landscape of weight loss pharmacotherapy in children and adolescents.
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