Related Experiment Video
Updated: Jan 17, 2026
06:26
Author Spotlight: Optimizing CFU Determination for Efficient Assessment of TB Vaccine Efficacy and Antigen Presentation Analysis
Published on: July 28, 2023
2.9K
Overview of the tuberculosis vaccine development landscape
1ICMR-National Institute for Research in Tuberculosis, Chetpet, Chennai, India.
The Indian Journal of Tuberculosis
|September 20, 2025
Summary
Developing new tuberculosis (TB) vaccines is crucial for TB elimination. Multiple vaccine candidates targeting diverse age groups are in clinical trials, addressing limitations of the current BCG vaccine.
Area of Science:
- Vaccinology
- Infectious Disease Epidemiology
- Public Health
Background:
- The current BCG vaccine has limitations in preventing tuberculosis (TB) disease across all age groups.
- Achieving TB elimination necessitates novel vaccines to reduce TB incidence.
Purpose of the Study:
- To review the landscape of novel tuberculosis vaccines currently in clinical development.
- To highlight the diverse approaches and challenges in developing effective TB vaccines.
Main Methods:
- Review of TB vaccines in clinical development (Phase I-III).
- Categorization of vaccines by type (viral vector, mycobacterial, protein subunit, mRNA) and intended use (prevention, therapeutic).
- Evaluation of strategies to expedite TB vaccine development.
Main Results:
- Approximately 17 TB vaccines are in various clinical trial phases.
- Vaccine candidates represent diverse platforms and target different stages of TB.
- BCG revaccination is also under investigation.
Conclusions:
- Developing a successful TB vaccine requires integrated efforts in basic science, clinical development, and public health research.
- Stakeholder engagement, funding, and advocacy are vital for accelerating new TB vaccine introduction.
Related Concept Videos
01:26Pulmonary Tuberculosis IV
479
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
479
01:28Pulmonary Tuberculosis V
543
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
543
01:29Pulmonary Tuberculosis I
844
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
844
01:28Pulmonary Tuberculosis II
1.4K
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
1.4K
01:31Pulmonary Tuberculosis III
941
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
The first classification is based on the development of the disease, and it includes the following categories:
941
01:29Microorganisms in Medicine and Therapeutics
987
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
987