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Updated: Jul 18, 2026

2D-HPLC-MS Technology Combined with Molecular Network for the Identification of Components in Tibetan Medicine Aconitum pendulum
Published on: December 8, 2023
Two novel 5,5-spiroketal sesquiterpenoid isomers from the roots of Angelica biserrata (R. H. Shan &Yuan) C. Q. Yuan &
Fuyong Ni1,2, Rongrong Li2, Zixian Xie1
1State Key Laboratory of Technologies for Chinese Medicine Pharmaceutical Process Control and Intelligent Manufacture, (Jiangsu Kanion Pharmaceutical Co.,Ltd. & Nanjing University of Chinese Medicine), Nanjing, Jiangsu, China.
Abstract:
Two novel 5,5-spiroketal sesquiterpenoid isomers, duhuosesquid A (1) and duhuosesquid B (2) were isolated from the roots of Angelica biserrata (R. H. Shan & Yuan) C. Q. Yuan & R. H. Shan. Their structures were determined by extensive spectroscopic analyses, and the absolute configurations of 1 and 2 were assigned via NMR calculations and ECD calculations. Additionally, their anti-inflammatory activities were evaluated through in vitro assays, with IC50 values of 15.9 ± 1.2 μM and 14.2 ± 0.5 μM, respectively.
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