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Updated: Jan 17, 2026
Author Spotlight: Advancements in DNA Nanosensors – Addressing Sensitivity and Selectivity Challenges in Molecular Detection
Published on: February 9, 2024
SiNWs-DNA nanoprobes functionalized microchannel for rapid and ultrasensitive virus sensing
Yueyue Feng1, Duo Zhang2, Shiwei Xu1
1Key Laboratory of Carbon Materials of Zhejiang Province, Key Lab of Biohealth Materials and Chemistry of Wenzhou, Institute of New Materials & Industry Technology, College of Chemistry & Materials Engineering, Wenzhou University, Wenzhou, 325027, Zhejiang, PR China.
None:
Accurate detection of low viral load infections is crucial for early diagnosis and effective prevention of virus transmission. However, most conventional virus detection methods are time-consuming and require complex nucleic acid amplification steps. Here, we present a glass microchannel sensor functionalized with silica nanowires-DNA (SiNWs-DNA) nanoprobes for simple, rapid, and ultrasensitive detection of Chikungunya virus (CHIKV). The detection is achieved via direct electrochemical signal acquisition after only a 9-min incubation. Without requiring nucleic acid amplification, the sensor achives a limit of detection (LOD) of 6.61 × 10-2 copies/μL, demonstrating enhanced sensitivity compared to conventional techniques such as reverse transcriptase polymerase chain reaction (RT-PCR). Furthermore, the platform exhibits excellent sensitivity and specificity in real sample analysis, underscoring its great potential in clinical virus diagnostics.
