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Unconventional bioprinting modalities for advanced tissue biofabrication
I Deniz Derman1, Myoung Hwan Kim2, Medine Dogan Sarikaya3
1Engineering Science and Mechanics Department, Penn State University, University Park, PA, 16802, USA; The Huck Institutes of Life Sciences, Penn State University, University Park, PA, 16802, USA.
Biomaterials
|September 21, 2025
Summary
Unconventional bioprinting methods overcome limitations of traditional techniques, enabling advanced tissue engineering. These innovative approaches promise scalable, complex tissue constructs for diverse applications.
Area of Science:
- Biotechnology
- Tissue Engineering
- Regenerative Medicine
Background:
- Conventional bioprinting faces challenges including low resolution, poor repeatability, limited speed, and scalability.
- These limitations hinder the fabrication of complex, functional three-dimensional tissue constructs.
Purpose of the Study:
- To review unconventional bioprinting modalities that address limitations of conventional methods.
- To explore emerging bioprinting techniques and their applications in tissue engineering.
- To discuss future directions for advancing bioprinting technologies.
Main Methods:
- Exploration of unconventional bioprinting modalities utilizing electric fields, acoustic waves, magnetic forces, light, smart materials, and microfluidics.
- Discussion of emerging methods like embedded, cryo-, microgravity, and 4D bioprinting.
- Review of applications in functional tissue engineering, disease modeling, and organoid development.
Main Results:
- Unconventional bioprinting modalities significantly improve resolution, repeatability, speed, and scalability compared to conventional methods.
- These advanced techniques facilitate the creation of complex, heterogeneous tissue constructs.
- Emerging bioprinting methods offer novel possibilities for tissue biofabrication.
Conclusions:
- Unconventional bioprinting represents a significant advancement over traditional techniques for creating sophisticated tissue constructs.
- Future directions include AI-driven bioprinting, multimodal biofabrication, and intraoperative bioprinting for enhanced clinical translation.
- Interdisciplinary innovations in unconventional bioprinting are crucial for advancing tissue biofabrication technologies.
