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Development of an Artificial Intelligence Powered Medication Risk Score Calculator Application.

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The Augmented Medication Risk Score (AUGMERIS) calculator uses AI to automate medication risk assessment, improving patient safety. This tool helps identify high-risk patients globally by analyzing drug combinations and kidney function.

Keywords:
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Area of Science:

  • Pharmacology
  • Artificial Intelligence
  • Health Informatics

Background:

  • Clinical pharmacists face challenges in evaluating complex medication therapies and identifying high-risk patients.
  • Processing unstructured electronic health records (EHRs) for medication risk assessment is a significant hurdle.
  • Existing methods may not efficiently integrate drug interactions and kidney function (e.g., eGFR) into risk scores.

Purpose of the Study:

  • To develop and validate the Augmented Medication Risk Score (AUGMERIS) calculator, an AI-powered web application.
  • To automate the evaluation of medication therapies using the Danish Medication Risk Score (MERIS) method.
  • To create a globally accessible tool for identifying patients requiring medication reviews.

Main Methods:

  • Developed a hybrid text processing model combining traditional algorithms with Generative Pre-trained Transformer (GPT) technology.
  • Integrated the text processing model and automated risk calculation into a web application using Python 3 and Streamlit.
  • Validated the application's performance using data from volunteer testers in eight countries.

Main Results:

  • The AUGMERIS web application successfully automates medication risk assessment, integrating drug combinations and eGFR.
  • The hybrid text processing model effectively handles unstructured EHR data for risk evaluation.
  • 383 trial calculations were performed by volunteer testers, indicating satisfactory performance despite validation limitations.

Conclusions:

  • The AUGMERIS calculator has the potential to significantly improve global pharmacotherapy and patient safety.
  • Wider adoption of AUGMERIS can enhance medication reviews and optimize treatments across diverse healthcare systems.
  • The tool demonstrates the feasibility of using AI for automated medication risk assessment in clinical practice.