Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bipolar Disorder01:30

Bipolar Disorder

628
Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
628
Attention-Deficit/Hyperactivity Disorder01:30

Attention-Deficit/Hyperactivity Disorder

787
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
787
Mania and Antimanic Drugs: Overview01:24

Mania and Antimanic Drugs: Overview

561
Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as...
561
Oppositional Defiant Disorder01:30

Oppositional Defiant Disorder

642
A persistent pattern of angry or irritable mood, defiant behavior, or vindictiveness characterizes Oppositional Defiant Disorder (ODD). Symptoms must occur over at least six months, involve interactions with individuals beyond siblings, and meet specific diagnostic criteria to be clinically significant. The disorder affects emotional regulation, social interactions, and behavior, often manifesting early in life and influencing long-term development and functioning.
Diagnostic Criteria and...
642

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Investigating functional connectivity differences during food vs. monetary reward processing across appetitive phenotypes of major depressive disorder.

Journal of affective disorders·2026
Same author

Neurodevelopmental and behavioral correlates of household structure independent of socioeconomic status.

Psychoradiology·2026
Same author

Resilience as a moderator of the association between emotion regulation difficulties and depressive symptoms in late adolescence and young adulthood.

The British journal of clinical psychology·2026
Same author

Mapping relative proximity within an internalizing symptoms network.

Journal of anxiety disorders·2026
Same author

Interventions that strengthen the patient-clinician relationship improve healthcare outcomes: An updated systematic review and meta-analysis.

Patient education and counseling·2026
Same author

Brain age prediction in generalized anxiety disorder using a convolutional neural network.

Translational psychiatry·2026

Related Experiment Video

Updated: Jan 17, 2026

Measurement of Fronto-limbic Activity Using an Emotional Oddball Task in Children with Familial High Risk for Schizophrenia
13:08

Measurement of Fronto-limbic Activity Using an Emotional Oddball Task in Children with Familial High Risk for Schizophrenia

Published on: December 2, 2015

9.3K

Neurostructural Differences Associated With Prodromal Mania Symptoms in Children.

Camille Archer1, Amy Milewski1, Hee Jung Jeong2

  • 1Department of Psychology, Vanderbilt University, Nashville, Tennessee, USA.

Brain and Behavior
|September 22, 2025
PubMed
Summary

Children with early mania symptoms show reduced gray matter volume, indicating smaller overall brain size. These brain structure differences may help identify youth at risk for bipolar disorder.

Keywords:
brain structurechildrengray matter volumemaniapathophysiology

More Related Videos

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis
05:52

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis

Published on: November 21, 2013

15.4K
Event Related Potentials ERPs and other EEG Based Methods for Extracting Biomarkers of Brain Dysfunction: Examples from Pediatric Attention Deficit/Hyperactivity Disorder ADHD
10:02

Event Related Potentials ERPs and other EEG Based Methods for Extracting Biomarkers of Brain Dysfunction: Examples from Pediatric Attention Deficit/Hyperactivity Disorder ADHD

Published on: March 12, 2020

16.6K

Related Experiment Videos

Last Updated: Jan 17, 2026

Measurement of Fronto-limbic Activity Using an Emotional Oddball Task in Children with Familial High Risk for Schizophrenia
13:08

Measurement of Fronto-limbic Activity Using an Emotional Oddball Task in Children with Familial High Risk for Schizophrenia

Published on: December 2, 2015

9.3K
Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis
05:52

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis

Published on: November 21, 2013

15.4K
Event Related Potentials ERPs and other EEG Based Methods for Extracting Biomarkers of Brain Dysfunction: Examples from Pediatric Attention Deficit/Hyperactivity Disorder ADHD
10:02

Event Related Potentials ERPs and other EEG Based Methods for Extracting Biomarkers of Brain Dysfunction: Examples from Pediatric Attention Deficit/Hyperactivity Disorder ADHD

Published on: March 12, 2020

16.6K

Area of Science:

  • Neuroscience
  • Child Psychiatry
  • Developmental Psychology

Background:

  • Prodromal mania symptoms in children predict future bipolar disorder.
  • Neurostructural correlates of early mania symptoms are not well understood.

Purpose of the Study:

  • Investigate the association between prodromal mania symptoms and brain structure in a large pediatric cohort.
  • Examine concurrent and longitudinal associations between mania symptoms and gray matter volume.

Main Methods:

  • Analyzed data from 10,662 children (9-10 years old) from the Adolescent Brain Cognitive Development (ABCD) Study.
  • Utilized structural equation modeling to assess brain structure and mania symptoms.
  • Controlled for age, sex, socioeconomic status, and medication use.

Main Results:

  • Baseline mania symptoms correlated with reduced gray matter volume in cortical and subcortical areas (global effect).
  • The association between mania symptoms and gray matter volume was linked to smaller overall brain size.
  • Brain volume at baseline did not predict future mania symptoms at follow-up.

Conclusions:

  • Findings support structural differences seen in adults with bipolar disorder.
  • Refines understanding of neurostructural links to childhood prodromal mania.
  • Potential to improve early identification and intervention for at-risk youth.