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Updated: Jan 17, 2026

A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
Published on: February 16, 2020
Regioselective Formal β-C(sp3)-H Amidation of Ketones by Merging Photocatalysis and Ni-Nitrenoid Transfer
Hyeyun Keum1,2, Harin Ryoo1,2, Dongwook Kim1,2
1Center for Catalytic Hydrocarbon Functionalizations, Institute for Basic Science (IBS), Daejeon 34141, South Korea.
Abstract:
β-Amino carbonyls are synthetically valuable scaffolds that are prevalent in bioactive molecules and pharmaceuticals, yet efficient and selective methods for their synthesis remain underdeveloped. Disclosed herein is a dual photoredox/nickel-catalyzed platform for the formal β-C(sp3)-H amidation of ketones to access β-amido ketones. The method enables the regioselective β-amidation of both cyclic and linear ketones under mild conditions, employing silyl enol ethers and dioxazolones as readily available coupling partners. Mechanistic studies support the involvement of a photogenerated allylic carbon radical, which engages with Ni-nitrenoid species to facilitate C(sp3)-N bond formation.
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