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Updated: Jan 17, 2026

A Rat Model of Pressure Overload Induced Moderate Remodeling and Systolic Dysfunction as Opposed to Overt Systolic Heart Failure
Published on: April 30, 2020
Impact of sleep apnea severity on left ventricular remodelling
Vutukuri Kiranmai1, Amoolya Rao Amaravadhi2, Vaishnavi Jamched3
1Department of General Medicine, Sri Devaraj Urs Medical College, Tamaka, Kolar-563103, Karnataka, India.
Abstract:
Sleep apnea is a common but often overlooked condition strongly associated with cardiovascular dysfunction, particularly left ventricular (LV) remodeling. This longitudinal study assessed changes in LV structure and function over time across sleep apnea severity groups defined by the apnea-hypopnea index (AHI). Serial echocardiographic evaluations revealed that moderate-to-severe sleep apnea was significantly correlated with increased LV mass index, systolic and diastolic dysfunction. Greater AHI severity and lack of treatment were linked to more progressive LV impairment. These results emphasize the need for early diagnosis and management of sleep apnea to reduce its long-term cardiac impact.
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