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Synchronous Recurrent Merkel Cell Carcinoma and Primary Cutaneous Melanoma: A Rare Case Report
Nektarios Ntalakos1, Maria Arnaouti1, Evdokia Arkoumani1
1Department of Pathology, Saint Savvas Anticancer Hospital of Athens, Athens, GRC.
Cureus
|September 22, 2025
Summary
Synchronous Merkel cell carcinoma and superficial spreading melanoma are exceptionally rare. This case highlights shared risk factors like UV radiation and immunosenescence, emphasizing a multidisciplinary approach for diagnosis and treatment.
Area of Science:
- Dermatology
- Oncology
- Pathology
Background:
- Merkel cell carcinoma (MCC) is a rare, aggressive neuroendocrine skin cancer.
- Superficial spreading melanoma (SSM) is a common skin cancer arising from melanocytes.
- Synchronous occurrence of MCC and SSM is exceedingly rare.

