Recent advances in the total synthesis of type III post-Iboga alkaloids
Xian-Yue Zhang1, Xin Wang2, Yue-Jie Zhu2
1School of Pharmaceutical Engineering, and Key Laboratory of Structure-Based Drug Design & Discovery (Ministry of Education), Shenyang Pharmaceutical University, Shenyang110016, China.
Abstract:
The total synthesis of post-Iboga alkaloids poses formidable challenges. So far, three groups have produced notable advancements through their endeavor. Sunkyu Han's group employed a ring-opening functionalization approach to accomplish semi-synthesis. Fu-she Han's group developed an asymmetric Michael/aldol tandem reaction to construct the aza-[3.3.1] bridged skeleton. Namba's group reported a one-pot tandem cyclization strategy to rapidly assemble the pentacyclic core of (±)-tronocarpine. This review focuses on the synthetic advances made from 2019 onward toward type III post-Iboga alkaloids, highlighting key strategic elements and synthetic milestones, and aims to inspire future endeavors in the total synthesis of this unique family.
More Related Videos
Related Concept Videos
Preparation of 1° Amines: Gabriel Synthesis
Strong bases like NaOH or KOH deprotonate the phthalimide to form the corresponding anion, which acts as a nucleophile. Further, the anion attacks an...
Preparation of 1° Amines: Azide Synthesis
Azide ions act as good nucleophiles and react with unhindered alkyl halides to form alkyl azides. Alkyl azides do not participate in further nucleophilic substitution reactions, thereby eliminating the chances of polyalkylated products. Alkyl azides are reduced by hydride-based reducing agents, like lithium aluminum...
Preparation of 1° Amines: Hofmann and Curtius Rearrangement Overview


