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Therapeutic Materials for Ferroptosis Inhibition: from Design to Applications.

Zipei Zhao^1,2, Hanfei Li¹, Xu Wang¹

¹State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 610041, China.

Advanced Healthcare Materials

|September 22, 2025

Summary

Ferroptosis, a cell death process, plays a key role in disease. Novel materials offer improved ferroptosis inhibition, overcoming limitations of traditional drugs for better therapeutic outcomes.

Keywords:

ROS ferroptosis iron homeostasis lipid peroxidation materials

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Area of Science:

Biomedical Science
Materials Science
Pathology

Background:

Ferroptosis, an iron-dependent cell death, is implicated in disease pathogenesis.
Inhibiting ferroptosis shows therapeutic potential, but traditional inhibitors have limitations.
Novel materials offer targeted and sustained ferroptosis inhibition.

Purpose of the Study:

To review ferroptosis, its role in diseases, and therapeutic targets.
To introduce diverse materials for ferroptosis therapy and their design principles.
To outline challenges and opportunities in developing ferroptosis-targeting materials.

Main Methods:

Literature review of ferroptosis mechanisms and therapeutic strategies.
Analysis of novel materials designed for ferroptosis inhibition.
Exploration of pathological microenvironment targeting strategies.

Main Results:

Ferroptosis is a critical mechanism in various diseases.
Novel materials demonstrate enhanced targeting and efficacy in ferroptosis inhibition.
Material design principles for pathological microenvironment targeting are established.

Conclusions:

Ferroptosis inhibition is a promising therapeutic avenue.
Advanced materials offer improved solutions over traditional ferroptosis inhibitors.
This review provides a framework for developing next-generation ferroptosis-targeting materials.