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Regulated cell death in endometrial diseases: from molecular mechanisms to targeted therapies
1Center of Reproductive Medicine, Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China.
Abstract:
Regulated cell death (RCD) is a fundamental biological process essential for tissue homeostasis and disease regulation. Increasing evidence has demonstrated that RCD plays a pivotal role in the pathogenesis of uterine endometrial diseases, including endometriosis, abnormal decidualization, endometrial receptivity defects, and intrauterine adhesions. However, a comprehensive synthesis centered on the roles of RCD in endometrial diseases is still lacking. This review systematically summarizes the roles of various RCD pathways-apoptosis, autophagy, ferroptosis, pyroptosis, and cuproptosis-in endometrial diseases, emphasizing their interactions with hormonal signaling, molecular mechanisms in different endometrial cells, and cell-cell communication. It also evaluates therapeutic strategies targeting RCD, offering insights into potential interventions for diseases, such as endometriosis, intrauterine adhesion, and embryo implantation failure.
Insights
Regulated cell death (RCD) pathways are crucial in uterine endometrial diseases like endometriosis. This review synthesizes RCD
Area of Science:
- Reproductive biology and molecular medicine
Background:
- Regulated cell death (RCD) is vital for tissue homeostasis.
- RCD pathways significantly contribute to uterine endometrial diseases, including endometriosis and intrauterine adhesions.
- Existing literature lacks a comprehensive review on RCD's role in endometrial pathologies.
Purpose of the Study:
- To systematically review the involvement of various RCD pathways (apoptosis, autophagy, ferroptosis, pyroptosis, cuproptosis) in endometrial diseases.
- To explore the interplay between RCD, hormonal signaling, and cellular mechanisms within endometrial cells.
- To evaluate RCD-targeting therapeutic strategies for endometrial conditions.
Main Methods:
- Systematic literature review and synthesis.
- Analysis of molecular mechanisms and cell-cell communication in RCD.
- Evaluation of current and potential therapeutic interventions.
Main Results:
- Apoptosis, autophagy, ferroptosis, pyroptosis, and cuproptosis are implicated in endometriosis, abnormal decidualization, and intrauterine adhesions.
- RCD pathways interact with hormonal signaling and exhibit distinct mechanisms in various endometrial cells.
- Therapeutic strategies targeting RCD show promise for treating endometrial diseases.
Conclusions:
- RCD pathways are central to the pathogenesis of diverse uterine endometrial diseases.
- Understanding RCD mechanisms offers novel therapeutic avenues for conditions like endometriosis and intrauterine adhesions.
- Targeting RCD presents a promising strategy for improving reproductive health and treating endometrial disorders.
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