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Updated: Jan 6, 2026

Multidisciplinary Approach to Obesity Management: A Case Report
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Adaptive vs Monthly Support for Weight-Loss Maintenance: A Randomized Clinical Trial.

Kathryn M Ross1,2,3, Meena N Shankar1, Peihua Qiu4

  • 1Department of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, Gainesville.

JAMA Network Open
|September 22, 2025
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Summary
This summary is machine-generated.

Adaptive telephone-based weight loss maintenance care did not significantly reduce weight regain compared to a static schedule. Both approaches effectively supported long-term weight management in adults with obesity.

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Area of Science:

  • Obesity research
  • Behavioral medicine
  • Public health

Background:

  • Weight regain is a significant challenge following initial weight loss interventions.
  • Extended care programs modestly improve long-term weight management.
  • Current extended care often involves monthly sessions, with limited impact.

Purpose of the Study:

  • To compare adaptive vs. static telephone-based extended care for reducing weight regain.
  • To assess the efficacy of an algorithm-triggered adaptive schedule against a fixed monthly schedule.

Main Methods:

  • Randomized clinical trial with 255 adults with obesity.
  • 16-week initial weight-loss program followed by 20 months of telephone support.
  • Intervention groups: adaptive (algorithm-triggered) vs. static (monthly).

Main Results:

  • No significant difference in weight regain between adaptive (1.27 kg) and static (1.75 kg) groups.
  • Both groups maintained significant weight loss at 24 months.
  • Similar proportions maintained ≥5% weight loss (adaptive 59.5%, static 59.8%).

Conclusions:

  • Adaptive telephone-based extended care did not offer additional benefits over a static schedule for weight maintenance.
  • Future research should focus on refining predictive algorithms for weight regain.
  • Investigating implementation and dissemination of telephone-based interventions is warranted.