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Statin associated muscle symptoms in older adults
Elizabeth K Pogge1, Nicole K Early1
1Midwestern University College of Pharmacy, Glendale, AZ, USA.
Introduction:
Statins are strongly recommended to reduce major adverse cardiovascular events, making them widely prescribed by health-care providers. Despite this, statins are underutilized in older adults (≥65 years of age), partially related to the fear of adverse effects. Statin associated muscle symptoms (SAMS) are commonly cited as a reason for statin discontinuation.
Areas Covered:
This review discusses the incidence, contributing factors, and clinical trial data surrounding SAMS in older adults. An approach to treating older adults with SAMS is proposed.
Expert Opinion:
Treating older adults who experience SAMS is challenging. Utilizing shared decision-making, patients who experience SAMS may be successfully rechallenged with a statin. If a patient is unable to tolerate a statin, non-statin therapeutic options can be considered to reduce cholesterol and improve cardiovascular outcomes.
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