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Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...
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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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Microtubules are dynamic structures and can be regulated by microtubule targeting agents (MTAs). Microtubule destabilizing drugs are a class of MTAs that destabilize and prevent microtubules' polymerization. Both natural and synthetic chemicals can be found under this class of drugs. Vincristine and vinblastine, two vinca alkaloids, and colchicine were among the first to be discovered. These drugs can affect cells in various ways, either by inducing a change in cell morphology, preventing...
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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Nano-Curcumin for Cancer Therapy: A Strategic Approach to Improve Bioavailability and Modulate Tumor Resistance.

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Curcumin, a natural compound, shows anticancer promise but faces delivery challenges. Nanotechnology offers solutions by creating nanoformulations to improve its effectiveness against cancer and overcome drug resistance.

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Area of Science:

  • Pharmacology
  • Nanotechnology
  • Oncology

Background:

  • Curcumin exhibits potent anticancer activities, including apoptosis induction and proliferation inhibition.
  • Clinical use of curcumin is limited by poor water solubility, rapid metabolism, and low bioavailability.
  • Tumor microenvironments and multidrug resistance (MDR) pose significant challenges for cancer therapy.

Purpose of the Study:

  • To review nanoformulation (NF) strategies for enhancing curcumin's anticancer efficacy.
  • To explore how nanotechnology addresses curcumin's pharmacokinetic limitations and improves tumor targeting.
  • To discuss the potential of advanced nano-curcumin formulations in overcoming MDR and enhancing therapeutic precision.

Main Methods:

  • Review of various nanoformulations: polymeric nanoparticles, SLNs, liposomes, micelles, and dendrimers.
  • Analysis of design, targeting strategies, and tumor penetration capabilities of nano-curcumin.
  • Inclusion of stimulus-responsive and ligand-targeted nano-curcumin formulations.
  • Discussion of preclinical and clinical evidence for NF safety and translational potential.

Main Results:

  • Nanoformulations significantly improve curcumin's solubility, stability, and bioavailability.
  • Targeted NFs enhance drug delivery to tumors and improve penetration.
  • Advanced formulations demonstrate potential in overcoming multidrug resistance (MDR).
  • Preclinical and clinical data suggest favorable safety and efficacy profiles for nano-curcumin.

Conclusions:

  • Nanotechnology-based nanoformulations are crucial for overcoming curcumin's limitations in cancer therapy.
  • Targeted and stimulus-responsive NFs offer enhanced precision and efficacy.
  • Nano-curcumin holds significant promise for improved cancer treatment outcomes.