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Updated: Jan 17, 2026

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy
Lessons Learned From Provider Minder: A Provider Tracking Application for Improving Stroke Risk Screening in Sickle
Alyssa M Schlenz1, Shannon M Phillips, Judson Stevens
1Author Affiliations: Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado (Dr Schlenz); College of Nursing, Medical University of South Carolina, Charleston, South Carolina (Dr Phillips); Medpack Solutions, South Charleston, West Virginia (Mr Stevens); Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston, South Carolina (Mrs Williams); Department of Pediatrics, Columbia University, New York, New York (Dr Lee); Department of Pediatrics, George Washington School of Medicine & Health Sciences, Washington, District of Columbia (Dr Nickel); Department of Pediatrics, East Carolina University, Greenville, South Carolina (Dr Fuh); Department of Pediatrics, SSM Health Cardinal Glennon Children's Hospital, St. Louis, Missouri (Dr Dolatshahi), and Department of Medicine University of Alabama at Birmingham, Birmingham, Alabama (Dr Kanter).
Provider Minder, a novel app for tracking sickle cell anemia stroke risk in children, showed successes like adaptability and ease of use. Implementation challenges were noted, but perceived benefits outweighed barriers for this important screening tool.
Area of Science:
- Pediatric Hematology
- Health Informatics
- Public Health Interventions
Background:
- Sickle cell anemia poses a significant stroke risk in children.
- Effective screening for stroke risk is crucial in pediatric sickle cell disease management.
- A need exists for efficient tools to monitor stroke risk screening adherence.
Purpose of the Study:
- To describe the development of Provider Minder, a web-based application for monitoring stroke risk screening in children with sickle cell anemia.
- To evaluate the implementation process of Provider Minder across multiple clinical sites.
- To identify lessons learned from the development and implementation of this novel health informatics tool.
Main Methods:
- Provider Minder was developed using an iterative process.
- A process evaluation involved surveys and interviews with 13 study sites over 2 years.
- Data from providers and coordinators were analyzed thematically to assess implementation factors.
Main Results:
- Key success factors included stakeholder coordination, high adaptability, ease of use, low cost, and effective capture of missed screenings.
- Implementation challenges comprised time burden, data redundancy, and lack of electronic medical record integration.
- Perceived successes in screening adherence monitoring were reported by users.
Conclusions:
- Despite implementation barriers, the perceived successes of Provider Minder outweighed the challenges.
- Future applications require reduced healthcare complexity burden and improved electronic health record interoperability for enhanced success.
- Provider Minder demonstrates potential for improving stroke risk screening in pediatric sickle cell anemia, with future iterations benefiting from system integration.
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