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Updated: Jul 17, 2026
Prehospital Thrombolysis: A Manual from Berlin
Published on: November 26, 2013
Impact of timeline-based management on treatment efficiency and outcomes in acute ischemic stroke: a
Yu-Feng Li1,2, Guo-Qin Feng2,3, Yong-Ping Ao1,2
1Department of Emergency, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou, China.
Objective:
This study evaluated the impact of a timeline-based management protocol on treatment efficiency and short-term outcomes in acute ischemic stroke (AIS) patients.
Methods:
A quasi-experimental study compared two cohorts treated at a single emergency department: a control group (n = 138) receiving conventional care (January-June 2022) and an intervention group (n = 125) managed with a timeline-based protocol (August-December 2022). Key metrics included door-to-needle time (DTN), admission-to-puncture time, order-to-CT time, and order-to-platelet-result time. Thrombolysis rates, Glasgow Outcome Scale (GOS), Fugl-Meyer scores, and stroke-specific quality of life were also analyzed.
Results:
The intervention group showed significantly shorter DTN, puncture, CT, and platelet result times (p < 0.05), along with a higher thrombolysis rate. Significant improvements were also observed in GOS, motor function, and quality of life scores (p < 0.05).
Conclusion:
The timeline-based protocol, featuring parallel coordination and a rapid-response stroke team, reduced treatment delays and improved clinical outcomes in AIS patients. These results support the adoption of time-sensitive protocols to enhance stroke care efficiency and prognosis.
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