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Rational discovery of molecular glue degraders based on block chemistry

Junjie Wei1, Wenjing Feng2, Qingsong Chen1

  • 1Department of Medicinal Chemistry, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410013 Hunan, China; Hunan Key Laboratory of Small Molecules for Diagnosis and Treatment of Chronic Disease, Changsha 410013 Hunan, China; Hunan Key Laboratory of Organ Fibrosis, Changsha 410013 Hunan, China.

Drug Discovery Today
|September 22, 2025
PubMed

Keywords:
PROTACblock chemistrydrug discovery strategymolecular glue degraderrational discovery

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