Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chemotaxis and Direction of Cell Migration01:21

Chemotaxis and Direction of Cell Migration

4.4K
Cells can detect chemical cues in their environment and reorganize the cytoskeleton to migrate toward them or away from them. This directional migration, called chemotaxis, is essential during embryogenesis and development, immune response, tissue repair and regeneration, and reproduction. These chemical cues can either attract or repel the cell's movement. For example, axon development is determined by a combination of chemoattractants and chemorepellents that direct the growing axon...
4.4K
Cell Migration01:09

Cell Migration

18.6K
Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
18.6K
Cell Migration01:19

Cell Migration

6.4K
Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
6.4K
Cytoskeletal Coordination in Cell Migration01:32

Cytoskeletal Coordination in Cell Migration

5.4K
A migrating cell changes its shape during the cyclic events of attachment and detachment from the substratum and repositions the cell organelles correspondingly. These complex events are orchestrated by the dynamic cytoskeletal network comprising actin filaments, intermediate filaments, and microtubules. Cytoskeletal crosstalk — the direct and indirect communication between the different components — is crucial for this coordination. Direct communication involves various linker...
5.4K
Role of Myosin in Cell Migration01:18

Role of Myosin in Cell Migration

3.2K
Myosins are multimeric motor proteins involved in various cellular processes such as migration, adhesion, and proliferation. Myosin II is the most common type in animal cells, which binds and cross-links actin filaments.
Myosin II  is a hexamer comprising two heavy chains with globular heads and coiled-coil tails, two regulatory light chains, and two essential light chains. The ATPase sites on the myosin heads hydrolyze ATP, and the released phosphate generates the force for contraction....
3.2K
Microtubules in Cell Motility01:24

Microtubules in Cell Motility

4.5K
Microtubules are thick hollow cylindrical proteins that help form the cytoskeleton. Microtubules have varied roles in the cell. These filaments help form cellular appendages like cilia and flagella, which are responsible for locomotion. The cilia arise from basal bodies, separated from the main body by a membrane-like structure forming the transition zone. This zone is the gate for the entry of lipids and proteins, creating a unique composition of lipids and proteins in the ciliary membrane and...
4.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evaluation of long-term healthcare utilization and costs associated with COVID-19 among adults and children in the US.

Journal of medical economics·2026
Same author

Cellular mechanometabolism: stimuli and implications.

EMBO reports·2026
Same author

Heart Rate Variability in Adults from Low- and High-Altitude Origins Residing in a High-Altitude City: A Cross-Sectional Comparison.

High altitude medicine & biology·2026
Same author

Understanding the Patient Perspective: A Scoping Review of Communication Preferences in Surgical Oncology.

Journal of surgical oncology·2026
Same author

High-throughput Genome Wide CRISPR Knock Out mechanical sort identifies genes driving metastatic cancer cell softening.

bioRxiv : the preprint server for biology·2026
Same author

Diagnosing the electron density of plasma amplifiers using XUV vortex beams.

Optics express·2025

Related Experiment Video

Updated: Jan 17, 2026

A Simple Migration/Invasion Workflow Using an Automated Live-cell Imager
09:17

A Simple Migration/Invasion Workflow Using an Automated Live-cell Imager

Published on: February 2, 2019

8.2K

A Mechanometabolism Toolbox for Studying Cell Migration.

Katherine M Young1, Santiago Lopez1, Keefer Boone1

  • 1Department of Bioengineering, Rice University, Houston, Texas 77251, USA.

Cold Spring Harbor Perspectives in Biology
|September 22, 2025
PubMed
Summary

Cell migration depends on cell and environment mechanics. This review explores techniques linking cell migration, mechanics, and metabolism, emphasizing mechanobiology and mechanometabolism approaches.

More Related Videos

Concentric Gel System to Study the Biophysical Role of Matrix Microenvironment on 3D Cell Migration
11:43

Concentric Gel System to Study the Biophysical Role of Matrix Microenvironment on 3D Cell Migration

Published on: April 3, 2015

8.9K
Quantitative Analysis of Random Migration of Cells Using Time-lapse Video Microscopy
07:27

Quantitative Analysis of Random Migration of Cells Using Time-lapse Video Microscopy

Published on: May 13, 2012

17.2K

Related Experiment Videos

Last Updated: Jan 17, 2026

A Simple Migration/Invasion Workflow Using an Automated Live-cell Imager
09:17

A Simple Migration/Invasion Workflow Using an Automated Live-cell Imager

Published on: February 2, 2019

8.2K
Concentric Gel System to Study the Biophysical Role of Matrix Microenvironment on 3D Cell Migration
11:43

Concentric Gel System to Study the Biophysical Role of Matrix Microenvironment on 3D Cell Migration

Published on: April 3, 2015

8.9K
Quantitative Analysis of Random Migration of Cells Using Time-lapse Video Microscopy
07:27

Quantitative Analysis of Random Migration of Cells Using Time-lapse Video Microscopy

Published on: May 13, 2012

17.2K

Area of Science:

  • Mechanobiology
  • Cellular and Molecular Biology

Background:

  • Cell migration is influenced by the physical properties of both the cell and its surrounding environment.
  • Understanding the interplay between cell migration, mechanics, and metabolism is a growing area of research.

Purpose of the Study:

  • To review current techniques for studying cellular and extracellular mechanics in the context of cell migration.
  • To highlight emerging approaches in mechanobiology and mechanometabolism.
  • To emphasize the importance of a mechanical perspective in cell migration research.

Main Methods:

  • Review of existing literature on cell migration, mechanobiology, and mechanometabolism.
  • Discussion of various experimental techniques used to probe cellular and extracellular mechanical properties.
  • Exploration of methods integrating mechanical measurements with metabolic analyses.

Main Results:

  • Identification of diverse techniques for assessing mechanical properties relevant to cell migration.
  • Highlighting the integration of mechanical studies with metabolic assessments.
  • Showcasing the significance of mechanobiology and mechanometabolism in understanding cell migration.

Conclusions:

  • Studying cell migration through a mechanical lens, incorporating metabolic insights, is crucial for advancing the field.
  • New approaches in mechanobiology and mechanometabolism offer powerful tools for migration research.
  • A comprehensive understanding requires integrating physical and metabolic factors influencing cell movement.