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Topical Dexamethasone During Stapedotomy in Patients With Otosclerosis: A Randomized Clinical Trial
Behrooz Amirzargar1, Sepideh Zoafa1, Melika Karimi1
1Otorhinolaryngology Research Center, Department of Otolaryngology-Head and Neck Surgery, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.
The Laryngoscope
|September 23, 2025
Summary
Topical dexamethasone applied during stapedotomy significantly reduced postoperative vertigo and tinnitus in otosclerosis patients. While hearing outcomes showed improvement, air-bone gap changes were not statistically significant between groups.
Area of Science:
- Otolaryngology
- Neurosurgery
- Pharmacology
Background:
- Otosclerosis is a common cause of conductive hearing loss.
- Stapedotomy is a surgical procedure to treat otosclerosis.
- Postoperative symptoms like vertigo and tinnitus can impact patient recovery.
Purpose of the Study:
- To evaluate the efficacy of topical dexamethasone in improving hearing outcomes after stapedotomy.
- To assess the impact of topical dexamethasone on reducing postoperative symptoms such as pain, vertigo, and tinnitus in otosclerosis patients.
Main Methods:
- A randomized, single-blinded clinical trial was conducted with 70 otosclerosis patients.
- Patients were divided into two groups: one receiving stapedotomy with topical dexamethasone, the other without.
- Hearing outcomes (air-bone gap, SRT, WRS) and postoperative symptoms were compared between groups.
Main Results:
- The dexamethasone group showed significantly greater improvement in Speech Reception Threshold (SRT) and Word Recognition Score (WRS).
- Postoperative vertigo and tinnitus were significantly reduced in the dexamethasone group compared to the control group.
- No statistically significant difference was observed in the air-bone gap (ABG) improvement between the two groups.
Conclusions:
- Topical dexamethasone application during stapedotomy is effective in reducing postoperative vertigo and tinnitus.
- While hearing improvements were noted, particularly in SRT and WRS, the effect on ABG was not statistically significant.
- Dexamethasone may be a valuable adjunct in managing postoperative symptoms following stapedotomy for otosclerosis.
