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Updated: Jan 17, 2026
The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
Comparative Efficacy of Traditional Unani Medicine Formulations Versus Apremilast for Chronic Plaque Psoriasis: A
Sabreena Bashir1, Muzafar Din Ahmad Bhat2, Mohd Arshad Jamal3
1Assistant Professor, Department of Jild wa tazeenyat Government Unani Medical College and Hospital, Srinagar, Kashmir, India.
Background:
Psoriasis remains an incurable and recurrent condition despite modern treatment. Traditional Unani Medicine recommends numerous formulations for psoriasis, but with little supporting scientific evidence.
Primary Study Objectives:
The study aimed to evaluate the efficacy and safety of Majoon Mundi and Roghan Gul compared to apremilast and coconut oil in managing chronic plaque psoriasis (CPP).
Methods/Design:
The study was a randomized, open-label, standard-controlled clinical trial, with 33 participants. 20 patients completed the 6-week treatment course in the test group, while 10 patients completed the 6-week treatment course in the control group.
Setting:
The study was conducted at the National Institute of Unani Medicine (NIUM), Bangalore, India, from June 2021 to December 2021.
Participants:
Participants aged 18-60 years, of either gender, diagnosed with CPP, and based on psoriasis area and severity index (PASI) score.
Interventions:
The participants in the test group received 10 g of Majoon Mundi orally twice daily after meals and Roghan Gul for topical use twice daily, while the participants in the active control group received apremilast orally in a titrated dose and coconut oil as a topical application twice daily.
Outcome Measures:
The primary outcome of the study was a reduction in PASI score, and the secondary outcome was a reduction in dermatology life quality index (DLQI) score. Photographic assessments were conducted at the 14th, 28th, and 42nd day of the follow-up period.
Results:
Intragroup analyses revealed that the test and control groups experienced a statistically significant reduction in PASI and DLQI scores (P < .001). Intergroup analysis showed no statistically significant difference in the reduction of PASI and DLQI scores between groups (P = .772 and .775, respectively).
Conclusion:
This study found that together, Majoon Mundi and Roghan Gul are as effective as apremilast and coconut oil in decreasing PASI and DLQI scores for managing CPP.
Keywords:
apremilast, comparative study, herbal medicine, psoriasis, unani medicine.
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