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04:04
Asthma Detection Research Based on Voice Signal Processing and Machine Learning
Published on: July 22, 2025
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Respiratory-Responsive Vocal Biomarker for Asthma Exacerbation Monitoring: Prospective Cohort Study
Erik Larsen1, Xinyu Song1, Dale Joachim1
1Sonde Health, Somerville, MA, United States.
Journal of Medical Internet Research
|September 23, 2025
Summary
A novel smartphone-based vocal biomarker effectively detects asthma exacerbations in real-time. This digital tool shows promise for accessible, noninvasive daily monitoring of respiratory health in asthma patients.
Area of Science:
- Digital health
- Biomarkers
- Respiratory medicine
Background:
- Asthma exacerbations pose challenges due to limitations in conventional monitoring tools.
- Smartphone-based respiratory-responsive vocal biomarker (RRVB) offers a novel, noninvasive approach for dynamic respiratory health assessment.
- Previous studies demonstrated RRVB generalizability across respiratory conditions and populations.
Purpose of the Study:
- To evaluate the real-world, longitudinal performance of an RRVB tool for daily asthma exacerbation monitoring.
- To assess the efficacy of RRVB as a convenient real-time tool for monitoring asthma exacerbations and respiratory states.
Main Methods:
- Prospective cohort study of 84 adult asthma patients followed for 90 days.
- Daily submission of 6-second voice samples, peak expiratory flow measurements, and symptom surveys.
- Real-time RRVB score generation and calculation of risk ratios for exacerbation prediction.
Main Results:
- Elevated RRVB scores significantly increased the risk of asthma exacerbations (2.15-3.57 times higher).
- RRVB scores indicated momentary respiratory states rather than long-term asthma control.
- High user engagement (58%) and positive participant experience (93% ease of use, 89% positive experience).
Conclusions:
- The RRVB tool effectively detects asthma exacerbations and dynamic respiratory states in real-time.
- RRVB shows potential as a noninvasive, user-friendly digital biomarker for asthma management.
- Findings support the integration of voice-based tools for proactive, real-world asthma monitoring.
Keywords:
asthma managementdigital healthmHealthmobile healthpatient engagementremote monitoringrespiratory exacerbationvocal biomarkersMore Related Videos
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