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Related Concept Videos

Non-LTR Retrotransposons03:18

Non-LTR Retrotransposons

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As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
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Related Experiment Video

Updated: Jan 17, 2026

Molecular Profiling of the Invasive Tumor Microenvironment in a 3-Dimensional Model of Colorectal Cancer Cells and Ex vivo Fibroblasts
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Molecular Profiling of the Invasive Tumor Microenvironment in a 3-Dimensional Model of Colorectal Cancer Cells and Ex vivo Fibroblasts

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Integrative epitranscriptomic and transcriptomic characterization in human colorectal cancer.

Ting Gong1, Sudhir Kumar Rai2, Yong Zhu3

  • 1Department of Quantitative Health Sciences, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI 96813, USA.

Journal of Advanced Research
|September 23, 2025
PubMed
Summary
This summary is machine-generated.

This study reveals N6-methyladenosine (m6A) modifications are crucial in colorectal cancer (CRC) progression and immune response. Targeting m6A-modified genes like SIM2 offers potential for novel CRC diagnostics and therapeutics.

Keywords:
Colorectal cancerDiagnosisImmunotherapySingle-minded 2, NTMT1Survival outcomem6A modification

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Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer
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Area of Science:

  • Oncology
  • Molecular Biology
  • Epigenetics

Background:

  • Colorectal cancer (CRC) development mechanisms are not fully understood, hindering targeted therapies and early detection.
  • N6-methyladenosine (m6A) RNA methylation is implicated in CRC pathogenesis, but research is limited.
  • Understanding mRNA methylation's role is critical for advancing CRC treatment strategies.

Purpose of the Study:

  • To investigate the roles of m6A modifications in colorectal cancer (CRC).
  • To elucidate how mRNA methylation contributes to CRC development and progression.
  • To identify potential therapeutic targets based on m6A regulatory pathways.

Main Methods:

  • Comprehensive mapping of m6A peaks in CRC tissues using Methylated RNA Immunoprecipitation Sequencing (MeRIP-seq).
  • Integration of m6A and mRNA expression data to identify differentially modified and expressed genes.
  • Analysis of m6A-regulated gene expression in relation to immune infiltrates and xenograft models.

Main Results:

  • Identified 119 overlapping m6A peaks in 77 genes, revealing a prognostic signature associated with immune microenvironment and checkpoints.
  • SIM2 was identified as a key candidate with elevated m6A and expression in CRC, regulated by NTMT1 and YTHDF1.
  • Silencing SIM2 significantly suppressed tumor growth, indicating its therapeutic potential.

Conclusions:

  • Integrative analysis provides a valuable resource for understanding the CRC molecular landscape.
  • Findings offer new insights for improving CRC diagnostics, prognostics, and therapeutics.
  • m6A modifications represent promising targets for CRC immunotherapy and treatment strategies.