Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

557
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
557
Drug Dosing in Renal Diseases: Dose Adjustments Based on Drug Clearance and Elimination Rate Constant01:25

Drug Dosing in Renal Diseases: Dose Adjustments Based on Drug Clearance and Elimination Rate Constant

209
In patients with renal disease, dosage adjustments are necessary to maintain therapeutic plasma drug concentrations and prevent toxicity or subtherapeutic exposure. Renal impairment alters drug pharmacokinetics, especially in conditions like uremia, where changes such as prolonged elimination half-life and altered apparent volume of distribution can significantly affect drug disposition. These changes require careful modification of the dosing regimen to achieve the desired clinical...
209
Acute Kidney Injury V: Interprofessional Care01:20

Acute Kidney Injury V: Interprofessional Care

297
Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
297
Acute Kidney Injury VI: Nursing Management01:22

Acute Kidney Injury VI: Nursing Management

397
Acute Kidney Injury (AKI) results in an inability to maintain fluid, electrolyte, and acid-base balance. Effective nursing management is critical in improving patient outcomes and includes comprehensive patient assessment and targeted interventions.Comprehensive Patient AssessmentA detailed history collection is essential, focusing on any recent infections, nephrotoxic medication use, or chronic conditions such as hypertension and diabetes that may contribute to AKI. During the physical...
397
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

271
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
271
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

344
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
344

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

<i>Lactiplantibacillus plantarum</i> <sup>WJL</sup> ameliorates chronic kidney disease by inhibiting fibroblast growth factor 21 adaptive stress response via low protein diet.

Gut microbes·2026
Same author

Engineered Red Blood Cell-Derived Extracellular Vesicles With Klotho Peptide Protect the Kidney From Fibrosis.

Journal of extracellular biology·2026
Same author

Sequential therapeutic approach for the management of osteoporosis in people with chronic kidney disease.

Nature reviews. Nephrology·2026
Same author

From grassroots to strategy: advancing laboratory sustainability at Utrecht university.

RSC advances·2026
Same author

Nutritional Factors Affecting Uremic Toxin Production.

Toxins·2026
Same author

Kidney health for all: caring for people, protecting the planet.

American journal of hypertension·2026

Related Experiment Video

Updated: Jan 17, 2026

A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy
07:52

A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy

Published on: November 7, 2017

21.9K

A guide to uraemic toxicity.

Griet Glorieux1, Stéphane Burtey2, Pieter Evenepoel3

  • 1Department of Internal Medicine and Pediatrics, Nephrology Section, Ghent University Hospital, Ghent, Belgium. griet.glorieux@ugent.be.

Nature Reviews. Nephrology
|September 23, 2025
PubMed
Summary

Uraemic retention molecules (URMs) accumulate in kidney disease, acting as toxins or beneficial agents. Understanding URMs is crucial for developing new therapies to restore homeostasis in patients with kidney dysfunction.

More Related Videos

Removal of Trace Elements by Cupric Oxide Nanoparticles from Uranium In Situ Recovery Bleed Water and Its Effect on Cell Viability
09:23

Removal of Trace Elements by Cupric Oxide Nanoparticles from Uranium In Situ Recovery Bleed Water and Its Effect on Cell Viability

Published on: June 21, 2015

10.2K
Surgical Techniques for Catheter Placement and 5/6 Nephrectomy in Murine Models of Peritoneal Dialysis
07:11

Surgical Techniques for Catheter Placement and 5/6 Nephrectomy in Murine Models of Peritoneal Dialysis

Published on: July 19, 2018

15.9K

Related Experiment Videos

Last Updated: Jan 17, 2026

A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy
07:52

A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy

Published on: November 7, 2017

21.9K
Removal of Trace Elements by Cupric Oxide Nanoparticles from Uranium In Situ Recovery Bleed Water and Its Effect on Cell Viability
09:23

Removal of Trace Elements by Cupric Oxide Nanoparticles from Uranium In Situ Recovery Bleed Water and Its Effect on Cell Viability

Published on: June 21, 2015

10.2K
Surgical Techniques for Catheter Placement and 5/6 Nephrectomy in Murine Models of Peritoneal Dialysis
07:11

Surgical Techniques for Catheter Placement and 5/6 Nephrectomy in Murine Models of Peritoneal Dialysis

Published on: July 19, 2018

15.9K

Area of Science:

  • Nephrology
  • Metabolomics
  • Biochemistry

Background:

  • Kidney dysfunction leads to the accumulation of uraemic retention molecules (URMs), impacting homeostasis.
  • Over 150 URMs are known, with omics approaches identifying more, some classified as uraemic toxins due to adverse effects.
  • Emerging research highlights URMs with potential beneficial roles in counteracting disease progression.

Purpose of the Study:

  • To explore the dual role of URMs in kidney disease, encompassing both detrimental and beneficial effects.
  • To emphasize the need for a balanced perspective on uraemic retention for effective disease management.
  • To highlight the importance of understanding URM origins, kinetics, and biological profiles for therapeutic development.

Main Methods:

  • Review of current literature on uraemic retention molecules and uraemic toxins.
  • Analysis of omics data for identification of novel URMs.
  • Investigation into the pathophysiological effects and potential benefits of URMs.

Main Results:

  • URMs can exert harmful effects (uraemic toxins) or potentially beneficial effects.
  • The origins and impact of uraemic toxins on protein modifications are key research areas.
  • Novel URMs with counteracting properties are being identified.

Conclusions:

  • A comprehensive understanding of URMs, including their origins, kinetics, and context-dependent effects, is essential for kidney disease progression.
  • Interventions targeting transporter-mediated interorgan communication ('remote sensing and signalling') are vital for restoring homeostasis.
  • Preventive strategies for chronic kidney disease must consider the multifaceted roles of URMs and target early intervention.