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Updated: Jan 17, 2026
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O-Ring Aortic Banding Versus Traditional Transverse Aortic Constriction for Modeling Pressure Overload-Induced Cardiac Hypertrophy
Published on: October 6, 2022
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Clinical Outcomes Post-Transcatheter Aortic Valve Replacement in Patients With Hypertrophic Obstructive
Muhammad Usman Almani1, Vibhor Ahluwalia2, Muhammad Yousuf3
1Division of Cardiology, Jefferson Einstein Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
Summary
Transcatheter aortic valve replacement (TAVR) in patients with hypertrophic obstructive cardiomyopathy (HOCM) is associated with a significantly higher risk of in-hospital mortality. However, readmission outcomes were similar between HOCM and non-HOCM patients post-TAVR.
Area of Science:
- Cardiology
- Interventional Cardiology
- Cardiac Surgery
Background:
- Hypertrophic obstructive cardiomyopathy (HOCM) patients were historically excluded from transcatheter aortic valve replacement (TAVR) trials.
- Post-TAVR "suicide left ventricle" is a concern due to potential worsening of left ventricular outflow tract obstruction.
Purpose of the Study:
- To evaluate clinical and readmission outcomes for HOCM patients undergoing TAVR.
- To compare outcomes between TAVR patients with and without comorbid HOCM.
Main Methods:
- Utilized data from the National Inpatient and National Readmission Databases (2016-2020).
- Performed multivariable logistic regression for in-hospital mortality and clinical outcomes.
- Employed multivariable Cox regression for 30-day readmission assessment.
Main Results:
- Identified 534 HOCM patients (0.2%) among 296,670 TAVR cases.
- HOCM patients had a >3-fold increased risk of in-hospital mortality (aOR: 3.47).
- HOCM patients experienced higher rates of atrioventricular blocks, cardiogenic shock, acute kidney injury, and intubation; no difference in readmissions.
Conclusions:
- TAVR in HOCM patients is linked to significantly higher in-hospital mortality.
- Patients with HOCM face increased procedural complications during TAVR.
- Real-world data indicates elevated risks for HOCM patients undergoing TAVR.
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