Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Introduction to Fibroblasts

Introduction to Fibroblasts

Rudolph Virchow discovered spindle-shaped cells called fibroblasts in 1858. Inactive fibroblasts, called fibrocytes, become activated by various stimuli, such as growth factors and inflammatory cytokines. Activated fibroblasts play a crucial role in wound healing, inflammation, formation of new blood vessels, and cancer progression. Uncontrolled activation of fibroblasts results in fibrosis, the excess deposition of fibrous tissue, which can lead to scarring and affect normal organs. This...

Inhibition of Cdk Activity

Inhibition of Cdk Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...

Negative Regulator Molecules

Negative Regulator Molecules

Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Dual modes of action: direct regulation and ceRNA-mediated mechanisms of ncRNAs in dermal fibroblast senescence.

Frontiers in cell and developmental biology·2026

Same author

Follicle-stimulating hormone and cancer.

Cellular signalling·2026

Same author

Isolation of synovial fluid exosomes using phospholipid molecular imprinting technology and discovery of early diagnostic markers for osteoarthritis.

Analytical sciences : the international journal of the Japan Society for Analytical Chemistry·2026

Same author

Genome-wide identification and characterization of the phytochrome family in Gossypium: GhPHYB1 as a dual regulator of plant architecture and drought tolerance in upland cotton.

Plant physiology and biochemistry : PPB·2026

Same author

[Research on the Coordinated Mechanism of Medical Device Research and Evaluation in China and the United States].

Zhongguo yi liao qi xie za zhi = Chinese journal of medical instrumentation·2026

Same author

HadS, a membrane-associated 2-haloacid dehalogenase from the moderate halophile <i>Halobacillus andaensis</i> NEAU-ST10-40<sup>T</sup>, enhances saline-alkaline tolerance when heterologously expressed in <i>Escherichia coli</i> KNabc.

Frontiers in microbiology·2026

Search research articles

Related Experiment Video

Updated: Jan 17, 2026

Murine Dermal Fibroblast Isolation by FACS

Murine Dermal Fibroblast Isolation by FACS

Published on: January 7, 2016

Research progress on cell cycle arrest in dermal fibroblasts.

Meizhen Wu¹, Juanlie Luo¹, Wenling Yang¹

¹School of Pharmacy, Guangxi University of Chinese Medicine, Nanning, China.

Cell Cycle (Georgetown, Tex.)

|September 24, 2025

Summary

Cell cycle arrest in dermal fibroblasts is key to skin health, but prolonged arrest causes aging and disease. Understanding these mechanisms offers new therapeutic targets for skin regeneration and anti-aging.

Keywords:

Dermal fibroblasts TGF-β signaling pathway cell cycle arrest epigenetic regulation p53 signaling pathway skin aging

More Related Videos

Isolation of Papillary and Reticular Fibroblasts from Human Skin by Fluorescence-activated Cell Sorting

Isolation of Papillary and Reticular Fibroblasts from Human Skin by Fluorescence-activated Cell Sorting

Published on: May 7, 2019

Isolation, Culture, and Characterization of Primary Dermal Fibroblasts from Human Keloid Tissue

Isolation, Culture, and Characterization of Primary Dermal Fibroblasts from Human Keloid Tissue

Published on: July 28, 2023

Related Experiment Videos

Last Updated: Jan 17, 2026

Murine Dermal Fibroblast Isolation by FACS

Murine Dermal Fibroblast Isolation by FACS

Published on: January 7, 2016

Isolation of Papillary and Reticular Fibroblasts from Human Skin by Fluorescence-activated Cell Sorting

Isolation of Papillary and Reticular Fibroblasts from Human Skin by Fluorescence-activated Cell Sorting

Published on: May 7, 2019

Isolation, Culture, and Characterization of Primary Dermal Fibroblasts from Human Keloid Tissue

Isolation, Culture, and Characterization of Primary Dermal Fibroblasts from Human Keloid Tissue

Published on: July 28, 2023

Area of Science:

Dermatology
Cell Biology
Molecular Biology

Background:

Cell cycle arrest in dermal fibroblasts is crucial for skin homeostasis.
It plays a central role in various skin pathologies.
Understanding its triggers and mechanisms is vital for skin health.

Purpose of the Study:

To systematically review factors triggering cell cycle arrest in dermal fibroblasts.
To elucidate the molecular mechanisms, including p53, TGF-β/Smad, and Wnt/β-catenin pathways.
To discuss the dual effects of cell cycle arrest and highlight therapeutic strategies.

Main Methods:

Systematic literature review.
Analysis of endogenous and exogenous factors.
Focus on key signaling pathways (p53, TGF-β/Smad, Wnt/β-catenin).

Main Results:

Transient arrest aids DNA repair and regeneration.
Prolonged arrest leads to senescence, inflammation, collagen degradation, and fibrosis.
Advances in chemical compounds modulating cell cycle arrest are identified.

Conclusions:

Cell cycle arrest has dual effects on skin health.
Targeting cell cycle arrest offers potential for skin regenerative medicine and anti-aging therapies.
Further research is needed to address critical scientific questions.