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Related Concept Videos

Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy01:26

Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy

This lesson explores three gastrointestinal imaging techniques: radionuclide testing, colonic transit studies, and virtual colonoscopy.
Radionuclide Testing
Radionuclide testing is a sophisticated medical technique for assessing gastrointestinal motility. It focuses on gastric emptying and colonic transit time. Radioactive markers track the movement of food through the digestive system, providing insights into gastrointestinal disorders.
In gastric emptying studies, a meal's liquid and solid...

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Related Experiment Video

Updated: Jul 10, 2026

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Patient-Reported Outcomes After Neoadjuvant Therapy and Watch-and-Wait for Rectal Cancer: A Systematic Review and

Bailey K Hilty Chu1, Anthony Loria1, Totadri Dhimal1

  • 1From the Surgical Health Outcomes and Research Enterprise (SHORE), Department of Surgery, University of Rochester Medical Center, Rochester, NY.

Annals of Surgery Open : Perspectives of Surgical History, Education, and Clinical Approaches
|September 24, 2025
PubMed
Summary

Watch-and-wait (WW) for rectal cancer may reduce bowel symptoms and improve quality of life (QoL) compared to surgery. More research is needed to fully understand patient-reported outcomes (PROs) with WW versus other treatments.

Keywords:
patient-reported outcomesquality-of-liferectal cancerwatch-and-wait

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Area of Science:

  • Oncology
  • Gastroenterology
  • Surgical Oncology

Background:

  • Rectal cancer treatment advancements focus on oncologic outcomes and long-term effects.
  • Watch-and-wait (WW) offers organ preservation after neoadjuvant therapy for clinical complete response.
  • WW's impact on patient-reported outcomes (PROs) compared to proctectomy is not well understood.

Purpose of the Study:

  • To evaluate patient-reported outcomes (PROs) in rectal cancer patients treated with neoadjuvant therapy followed by watch-and-wait (WW).

Main Methods:

  • Systematic review and meta-analysis of 25 studies (3139 patients) reporting PROs.
  • Included patients with stage I-III rectal adenocarcinoma treated with neoadjuvant therapy and WW, proctectomy, or local excision.
  • Random-effects model meta-analysis and narrative synthesis were employed.

Main Results:

  • Meta-analyses showed fewer bowel symptoms and improved quality of life (QoL) in some subscales for WW compared to surgery.
  • 14 of 24 QoL comparisons favored WW in some subscales; 10 showed no difference.
  • 11 of 24 symptom scale comparisons favored WW; 13 showed no difference.

Conclusions:

  • WW may avoid permanent ostomy and surgical morbidity.
  • More robust data are needed to compare WW PROs with proctectomy or local excision.
  • Prioritizing publication of QoL data is crucial for informed shared decision-making.