Related Experiment Video

Updated: Jan 17, 2026

Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers
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Successful Treatment of Refractory Bilateral Leg Ulcers With an Adsorptive Blood-Purification Device

Asako Iida1, Goh Akiyama1, Kaoruko Matsunami1

  • 1From the Department of Plastic, Reconstructive and Aesthetic Surgery, Nippon Medical School Hospital, Tokyo, Japan.

Plastic and Reconstructive Surgery. Global Open
|September 24, 2025
PubMed

Insights

Rheocarna, a novel blood purification device, shows promise for treating chronic limb-threatening ischemia (CLTI) in patients ineligible for revascularization. This therapy improved circulation and ulcer healing, potentially preventing amputation in a challenging case.

Area of Science:

  • Vascular Medicine
  • Medical Devices
  • Nephrology

Background:

  • Chronic limb-threatening ischemia (CLTI) represents the most severe stage of lower extremity artery disease.
  • Patients with CLTI often present with complex comorbidities and limited treatment options, particularly if unsuitable for revascularization.
  • Existing therapies for CLTI have limitations, necessitating exploration of novel treatment modalities.

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