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Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway
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Programmed Cell Death in Diabetic Kidney Disease: Mechanisms and Therapeutic Targeting

Shanshan Tang1, Yuting Sun2, Wenjie Sun3,4

  • 1College of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, People's Republic of China.

Journal of Inflammation Research
|September 25, 2025
PubMed

Insights

Diabetic kidney disease (DKD) pathogenesis involves various programmed cell death (PCD) types, including apoptosis, autophagy, and pyroptosis. Understanding these PCD pathways is crucial for developing effective DKD therapies.

Area of Science:

  • Nephrology
  • Molecular Biology
  • Pathology

Background:

  • Diabetic kidney disease (DKD) presents a growing global health challenge with high mortality.
  • Programmed cell death (PCD) significantly influences DKD pathogenesis, acting in both homeostatic and pathological capacities.

Purpose of the Study:

  • To review and synthesize current knowledge on the role of diverse PCD pathways in DKD.
  • To explore the potential of PCD-targeted therapies for DKD treatment.

Main Methods:

  • Literature review synthesizing evidence on apoptosis, autophagy, pyroptosis, ferroptosis, necroptosis, and parthanatos in DKD.
  • Analysis of gene-regulated signaling pathways involved in PCD-mediated DKD progression.

Main Results:

  • Multiple PCD types, including apoptosis, autophagy, pyroptosis, and ferroptosis, are implicated in DKD progression.
  • Emerging evidence suggests complex interactions and crosstalk between different PCD pathways in DKD.
  • Recently identified PCD modes like necroptosis and parthanatos require further investigation in the context of DKD.

Conclusions:

  • Dissecting the multifaceted roles of PCD in DKD is essential for a deeper mechanistic understanding.
  • Targeting PCD pathways holds promise for developing novel therapeutic strategies for DKD.
  • Addressing current research limitations, such as unclear PCD interactions and translational gaps, is critical for clinical advancement.
Keywords:
apoptosisautophagydiabetic kidney diseaseferroptosisprogrammed cell deathpyroptosis

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