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Diagnostic and Prognostic Predictive Value of Serum Selenium and Redox Biomarkers in Retinal Vein Occlusion
Danqing Shen1, Meixiu Li1, Wencai Sun2
1Department of Ophthalmology, Taicang TCM Hospital Affiliated to Nanjing University of Chinese Medicine (Taicang Hospital of Traditional Chinese Medicine), Taicang, Suzhou, Jiangsu, People's Republic of China.
Objective:
To investigate the diagnostic efficacy and prognostic predictive value of serum selenium (Sse) and redox biomarkers in retinal vein occlusion (RVO).
Methods:
A prospective analysis was conducted on 112 RVO patients (RVO Group) admitted to the hospital between January 2022 and February 2024, along with 112 non-RVO ophthalmic patients (non-RVO Group) during the same period. The levels of Sse and redox factors [high mobility group protein B1 (HMGB1), reduced glutathione (GSH), nitric oxide (NO), and superoxide dismutase (SOD)] were compared between the two groups, and the receiver operating characteristic (ROC) curves were plotted to analyze their diagnostic efficacy for RVO. The RVO Group received treatment and was divided into poor prognosis group and good prognosis group based on prognosis. The changes in Sse and redox biomarker levels were compared to analyze factors influencing RVO patient prognosis, and a nomogram was constructed to validate the calibration curve.
Results:
Compared with the non-RVO group, the levels of Sse, GSH, and SOD were lower, while the levels of HMGB1 and NO were higher in the RVO group (P <0.05). The ROC curve showed that Sse and various oxidative stress factors had good diagnostic efficacy for RVO. In the Poor Prognosis Group, Sse, GSH, NO, and SOD levels were lower than those in the Good Prognosis Group, while HMGB1 levels were higher than those in the Good Prognosis Group (P <0.05). Cox regression analysis showed that all these indicators were factors influencing the prognosis of RVO patients (all P < 0.05). Additionally, the consistency of theroc curves constructed using these factors was good, and the calibration curves were close to the ideal curve.
Conclusion:
The combined detection of Sse and redox biomarkers can effectively assist in RVO diagnosis, while their dynamic changes have important clinical value in prognosis evaluation.
