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Synthesis and Reaction Chemistry of Nanosize Monosodium Titanate
Published on: February 23, 2016
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How TiO2 Nanomaterials are Emerging as Key Therapeutics in Stomatology
Junnan Qi1,2, Huimin Liu3, Huen Li1,2
1Hospital of Stomatology, Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, Jilin University, Changchun, 130021, People's Republic of China.
International Journal of Nanomedicine
|September 25, 2025
Summary
Titanium dioxide (TiO2) nanomaterials offer advanced solutions for oral diseases, including cancer, infections, and tissue repair. These versatile materials show promise for improved diagnostics, therapies, and dental materials, paving the way for precision oral medicine.
Area of Science:
- Nanomedicine
- Biomaterials
- Oral Medicine
Background:
- Conventional treatments for oral diseases face limitations like invasiveness and drug resistance.
- Titanium dioxide (TiO2) nanomaterials have emerged as promising therapeutic agents in oral medicine.
Purpose of the Study:
- To systematically review the applications and future prospects of TiO2 and TiO2-x nanomaterials in oral medicine.
- To evaluate their potential in cancer diagnosis/therapy, antibacterial treatment, tissue regeneration, drug delivery, dental materials, and teeth whitening.
Main Methods:
- Extensive literature search of PubMed and Web of Science databases.
- Systematic evaluation of TiO2 and TiO2-x nanomaterials' performance in various oral health domains.
Main Results:
- TiO2 nanomaterials demonstrate high sensitivity and specificity in oral cancer diagnosis (100% sensitivity, 95.83% specificity).
- Achieve >99% antibacterial efficiency against oral pathogens via reactive oxygen species (ROS).
- Enhance bone-implant contact by 1.5-fold and improve resin hardness by >200% with minimal addition.
- TiO2-x shows comparable teeth whitening to commercial products using a lower H2O2 concentration.
Conclusions:
- TiO2-based nanomaterials offer a paradigm shift towards precision oral medicine due to biocompatibility and multifunctionality.
- Further research is needed to address challenges in synthesis, biosafety, and regulatory frameworks for clinical translation.
