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Pathways Linking Parental Social Support and Decision-Making Participation to Medication Adherence in Children With

Chunsong Yang1,2, Rui Huang3, Qiuji Tao4

  • 1Department of Pharmacy, Evidence-Based Pharmacy Center, West China Second Hospital, Sichuan University, Chengdu, China.

Depression and Anxiety
|September 25, 2025
PubMed

Insights

Parental social support and shared decision-making improve pediatric epilepsy medication adherence, with treatment satisfaction acting as a mediator. Parental anxiety can hinder these positive effects, underscoring the need for comprehensive support strategies.

Area of Science:

  • Pediatric Neurology
  • Clinical Pharmacy
  • Health Psychology

Background:

  • Suboptimal medication adherence is common in pediatric epilepsy.
  • The influence of parental social support, decision-making participation, treatment satisfaction, and anxiety on adherence is not fully understood.

Purpose of the Study:

  • To investigate the direct and indirect effects of parental factors on medication adherence in pediatric epilepsy.
  • To examine the mediating role of treatment satisfaction and the moderating role of parental anxiety.

Main Methods:

  • Cross-sectional study with 1056 pediatric epilepsy patients.
  • Utilized structural equation modeling (SEM) and moderation analysis.
  • Assessed medication adherence, social support, communication/decision-making, treatment satisfaction, and parental anxiety.

Main Results:

  • Parental social support, decision-making participation, and treatment satisfaction positively impacted medication adherence.
  • Social support and decision-making participation significantly influenced treatment satisfaction.
  • Treatment satisfaction mediated the relationship between social support/decision-making and adherence.
  • Parental anxiety weakened the positive effects of support, participation, and satisfaction on adherence.

Conclusions:

  • An integrated model demonstrates how parental factors influence pediatric epilepsy medication adherence.
  • Treatment satisfaction is a key mediator, while parental anxiety acts as a moderator.
  • Interventions should focus on enhancing parental support, communication, satisfaction, and managing anxiety to improve adherence.

Keywords:
medication adherenceparental anxietyparental decision-makingpediatric epilepsysocial support

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