Injectable Safety: New Concepts and Best Practices in Hyaluronic Acid Filler Safety
R Brannon Claytor1, Grace C Tolan1,2
1From the Claytor Noone Plastic Surgery.
Plastic and Reconstructive Surgery
|September 25, 2025
Summary
Educated injectors using proper hyaluronic acid injection techniques and understanding facial anatomy are crucial for patient safety. This knowledge helps minimize complications with new aesthetic injectable products.
Area of Science:
- Aesthetic Medicine
- Dermatology
- Cosmetic Surgery
Background:
- The hyaluronic acid (HA) industry is rapidly expanding with new products.
- Injector education on anatomy, technique, and product properties is vital for patient safety and satisfaction.
Purpose of the Study:
- To review current literature on hyaluronic acid fillers.
- To identify key factors influencing safety and efficacy in aesthetic injections.
Main Methods:
- Comprehensive literature search of Ovid and MEDLINE/PubMed databases.
- Keywords included "filler," "hyaluronic acid," "complications," "injection technique," "safety," and "facial anatomy."
- Screening and selection of 34 relevant publications from 2020-2025.
Main Results:
- A systematic review process identified 34 key articles for analysis.
- The literature highlights the importance of injector knowledge and technique.
Conclusions:
- Deep understanding of facial anatomy and HA product properties is essential.
- Proper injector technique and experience are critical for reducing complications.
- Crosslinking technology and injector expertise are key to safe HA filler use.
