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Published on: August 6, 2019
Actinomycetoquinones A-E, Anthraquinone-γ-Pyrones Discovered from Marine-Derived Actinomycetospora sp. Bacterium
Fan Zhang1, Christopher D Roberts1, Tae Hyun Lee1
1Pharmaceutical Sciences Division, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.
Abstract:
Facilitated by LC-MS-PCA metabolomics methods and effective molecular networking for strain prioritization and dereplication, five new anthraquinone-γ-pyrones, actinomycetoquinones A-E (1-5), were isolated from a marine-derived Actinomycetospora sp. bacterium. The structures of 1-5 were elucidated by analysis of their HRMS and NMR spectroscopic data. The absolute configuration of 1 was unequivocally determined by single-crystal X-ray diffraction analysis using Cu Kα radiation. Actinomycetoquinone C exhibited antibacterial activity against methicillin-resistant S. aureus (MRSA) and E. coli with MIC values of 1 and 4 μg/mL, respectively.
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