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Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Organophotocatalytic Decarboxylative Allylation of Carboxylic Acids with Allylic Acetates
Chengyang Ju1, Xiaoyu Liu1, Yanzhe Shi1
1School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816, China.
Abstract:
We developed an acridine-catalyzed, metal- and base-free decarboxylative allylation of carboxylic acids with allylic acetates under mild conditions. The reaction proceeds via a proton-coupled electron transfer (PCET) process, enabling efficient conversion of readily available feedstocks with broad functional group compatibility. This operationally simple and versatile method demonstrates significant potential for synthetic applications, particularly in late-stage modification of bioactive carboxylic acids.
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