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Updated: Jan 16, 2026

Quantifying Replication Stress in Ovarian Cancer Cells Using Single-Stranded DNA Immunofluorescence
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Multiple roles of replication factor C family in pan‑cancer (Review)

Dan Luo1, Bo Li2, Xueping Jiang2

  • 1The Minda Hospital, Hubei Minzu University, Enshi, Hubei 445000, P.R. China.

Oncology Reports
|September 26, 2025
PubMed

Insights

The replication factor C (RFC) family plays a key role in cancer progression. This review systematically examines RFC

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • Cancer continues to have high global incidence and mortality rates, necessitating novel therapeutic strategies.
  • The replication factor C (RFC) family is crucial for DNA replication and repair, with significant roles in tumor progression.
  • The specific contributions of individual RFC family members to cancer hallmarks remain incompletely understood.

Purpose of the Study:

  • To systematically review the multifaceted roles of the RFC family in cancer.
  • To profile RFC family mRNA expression across various cancer types and evaluate its association with tumor types and patient survival.
  • To elucidate the signaling pathways, molecular mechanisms, and clinical significance of RFC members in malignancies.

Main Methods:

  • Pan-cancer analysis of mRNA expression for each RFC family member.
  • Evaluation of associations between RFC expression levels and tumor types.
  • Assessment of RFC expression's impact on patient survival across malignancies.
  • Summary of current research on RFC family members and RFC-like complexes in various malignancies.
  • Discussion of associated signaling pathways, molecular mechanisms, and clinical implications.

Main Results:

  • RFC family members exhibit varied mRNA expression patterns across different cancer types.
  • RFC expression levels correlate with specific tumor types and impact patient prognosis.
  • Detailed insights into RFC family's role in tumor biology, signaling pathways, and molecular mechanisms were summarized.

Conclusions:

  • The RFC family, including RFC-like complexes, is integral to cancer biology and progression.
  • Understanding RFC family member expression and function offers prognostic value and identifies potential therapeutic targets.
  • This review provides a foundation for developing novel, combinatorial molecular targeted therapies for cancer.
Keywords:
functionpan‑cancerreplication factor C familysignaling pathwaystructure

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