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Updated: Jan 16, 2026

Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines
Published on: June 23, 2019
Synthesis and Evidence for the Stereo/Region-Specific Structure of
Denis D Chirkov1, Iliya I Butorin1, Oleg S Eltsov1
1Ural Federal University, Yekaterinburg, Russian Federation.
None:
The series of new 2-substituted-5,7-di(het)aryl-6-nitro-4,5,6,7-tetrahydroazolo[1,5-a]pyrimidines were synthesized by reaction between imine and 1-substituted 2-nitroethylene derivatives. The structure of the obtained compounds including stereochemical configuration was confirmed by NMR techniques such as 1H, 13C, 2D 1H-1H (gNOESY), 1H-13C (gHSQC, gHMBC) 2D 1H-15N gHMBC and XRD method, additionally. For the obtained compounds, the signals of all hydrogen, carbon, and nitrogen nuclei in the NMR spectra were associated using two-dimensional NMR experiments. Based on the analysis of the spin-spin coupling constants (SSCC), it was found that the target compounds were obtained in the form of trans-trans isomers.
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