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Quantification of Efferocytosis by Single-cell Fluorescence Microscopy
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Metabolic reprogramming in efferocytosis.

Qing Yan1,2, Kuo Li1, Lu Chen1

  • 1College of Life Sciences, Shaanxi Normal University, Xi'an, China.

Frontiers in Cell and Developmental Biology
|September 26, 2025
PubMed
Summary
This summary is machine-generated.

Efferocytosis, the clearance of dead cells by phagocytes, triggers metabolic reprogramming. This metabolic shift dictates whether phagocytes resolve inflammation or promote disease, offering new therapeutic targets.

Keywords:
apoptotic cell clearanceefferocytosisfatty acid oxidationglycolysismacrophagesmetabolic reprogramming

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Area of Science:

  • Immunology
  • Metabolism
  • Cell Biology

Background:

  • Efferocytosis is crucial for tissue homeostasis, inflammation resolution, and repair.
  • Phagocyte metabolic reprogramming during efferocytosis influences their functional phenotype.
  • Metabolic reprogramming determines anti-inflammatory or pro-inflammatory outcomes.

Purpose of the Study:

  • To comprehensively analyze molecular mechanisms of metabolic reprogramming during efferocytosis.
  • To elucidate regulatory networks involving metabolites and signaling pathways.
  • To understand how glucose, lipid, and amino acid metabolism are modulated.

Main Methods:

  • Analysis of molecular regulatory mechanisms.
  • Examination of signaling pathways and metabolite interactions.
  • Investigation of glucose, lipid, and amino acid metabolism regulation.

Main Results:

  • Metabolic reprogramming is essential for phagocyte function during efferocytosis.
  • Metabolites act as signaling molecules influencing phagocyte phenotype.
  • Efferocytosis signals regulate major metabolic pathways, impacting phagocyte function.

Conclusions:

  • Understanding metabolic reprogramming in efferocytosis provides insights into disease pathogenesis.
  • This interplay offers novel therapeutic targets for diseases with impaired apoptotic cell clearance.
  • Targeting metabolic pathways could shift phagocyte phenotype towards resolution.