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Updated: Jan 6, 2026

Oral Biofilm Sampling for Microbiome Analysis in Healthy Children

Oral Biofilm Sampling for Microbiome Analysis in Healthy Children

Published on: December 31, 2017

Microbiome differences between trauma- and caries-derived periapical lesions using next-generation sequencing.

Jiyuan Zhan¹, Yinxue Huang¹, Xinhui Meng¹

¹Yunnan Key Laboratory of Stomatology & Department of Cariology, Operative Dentistry and Endodontics, The Affiliated Stomatology Hospital, Kunming Medical University, Kunming, China.

Journal of Oral Microbiology

|September 26, 2025

Summary

This summary is machine-generated.

Trauma-derived periapical lesions show lower microbial diversity than caries-derived ones. Campylobacter is a key bacterium distinguishing trauma-induced lesions, suggesting it may be a diagnostic marker.

Keywords:

Trauma teeth campylobacter microbiome next-generation sequencing periapical lesions

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Last Updated: Jan 6, 2026

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Area of Science:

Oral microbiology
Endodontics
Microbial ecology

Background:

The microbiome of periapical lesions from caries is well-studied.
The microbial profile of periapical lesions resulting from trauma is not well understood.

Purpose of the Study:

To characterize the apical microbiome of trauma-derived periapical lesions.
To identify taxonomic differences between trauma- and caries-derived periapical lesions.

Main Methods:

Collected microbial samples from 20 patients (10 trauma, 10 caries).
Used Illumina sequencing of the 16S rRNA gene's V3-V4 regions.
Performed diversity and differential abundance analyses (LEfSe).

Main Results:

Identified 36 bacterial phyla and 587 genera.
Trauma group showed higher Campylobacter abundance (P=0.002).
Reduced abundance of Prevotella, Vibrio, and Filifactor in trauma cases.
Campylobacter identified as a biomarker for trauma-derived lesions.

Conclusions:

Trauma-derived periapical lesions have reduced microbial diversity.
Campylobacter is a potential pathognomonic taxon for trauma-derived periapical lesions.