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Updated: Jan 16, 2026

Analyzing Neural Activity and Connectivity Using Intracranial EEG Data with SPM Software
Published on: October 30, 2018
Overlooked neuroanatomical markers of face processing and developmental prosopagnosia in posteromedial cortex
Abstract:
Recent functional imaging studies implicate human posteromedial cortex (PMC)-composed of the posterior cingulate cortex, the precuneus, and retrosplenial cortex-in face processing. Separately, anatomical studies have identified previously overlooked cortical folds (sulci) in PMC associated with higher-level cognitive abilities. Here, we tested whether these newly identified sulci support face processing in neurotypical individuals and individuals with developmental prosopagnosia (DP). After manually labeling 1,642 sulci in 164 hemispheres, we first identified a gradient of face selectivity along the anterior-posterior axis of PMC that was consistent across three samples, including DP individuals. Second, we discovered a new anatomical locus in PMC that differed structurally and functionally between neurotypical and DP individuals. Finally, data-driven analysis revealed that right-hemisphere PMC sulcal morphology was associated with face recognition ability. These findings reveal a sulcal network in PMC that supports face processing, and they identify the first structural neuroanatomical marker of face processing deficits in PMC.
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