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Low Phospholipid-Associated Cholelithiasis Syndrome: A Case Report of Chronic Recurrent Cholangitis
Faris Bandar Alrashdan1, Ramy Mahmoud Fathy Elbarody1, Atheer Abdullah Ali Aldra2
1Head of Gastroenterology Department King Salman Specialist Hospital, Hail Health Cluster Hail Saudi Arabia.
Clinical Case Reports
|September 26, 2025
Summary
Low phospholipid-associated cholelithiasis (LPAC) syndrome causes recurrent bile duct stones. Early diagnosis and ursodeoxycholic acid treatment are key for managing this rare condition, especially in young adults post-cholecystectomy.
Area of Science:
- Gastroenterology
- Hepatology
- Biliary Medicine
Background:
- Low phospholipid-associated cholelithiasis (LPAC) syndrome is a rare cause of recurrent bile duct stones.
- It is often underdiagnosed, leading to delayed management and complications like cholangitis.
Purpose of the Study:
- To highlight the diagnostic challenges and management of LPAC syndrome.
- To emphasize the importance of considering LPAC in young adults with recurrent biliary symptoms post-cholecystectomy.
Main Methods:
- Case report of a 32-year-old male with recurrent cholangitis and bile duct stones.
- Management involved multiple ERCPs, stone extraction, biliary stenting, and diagnosis of LPAC syndrome.
- Treatment with ursodeoxycholic acid and follow-up imaging.
Main Results:
- The patient experienced recurrent episodes of cholangitis managed with ERCP and stenting.
- Diagnosis of LPAC syndrome was established, and treatment with ursodeoxycholic acid initiated.
- Follow-up showed persistent but improving biliary dilation without complications.
Conclusions:
- LPAC syndrome is a recurrent condition requiring early recognition and long-term management.
- Considering LPAC is crucial for young adults with unexplained biliary symptoms after cholecystectomy.
- Effective management can reduce recurrence and improve patient outcomes.
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