Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bulimia Nervosa01:30

Bulimia Nervosa

690
Bulimia nervosa is a complex and severe eating disorder characterized by a cyclical pattern of binge-and-purge eating pattern. It generally involves an episode of binge eating, followed by compensatory behaviors such as vomiting, excessive exercise, laxative use, or fasting, to prevent weight gain. Despite often maintaining a normal weight, individuals with bulimia are intensely preoccupied with their body image and harbor an overwhelming fear of gaining weight. This can contribute to the...
690
Anorexia Nervosa01:28

Anorexia Nervosa

988
Anorexia nervosa is a complex and severe eating disorder characterized by an intense fear of weight gain, an unrelenting pursuit of thinness, and a distorted body image. It often leads to dangerously low body weight relative to an individual's age and height. This disorder is marked by significant physical and psychological consequences, making it one of the most life-threatening psychiatric illnesses.
Symptoms and Physical Effects
Individuals with anorexia nervosa commonly exhibit extreme...
988
Assessment of the Gastrointestinal System II: Health Perception Pattern01:29

Assessment of the Gastrointestinal System II: Health Perception Pattern

455
Assessing the gastrointestinal (GI) system is a complex process that begins with collecting subjective data. This data, collected through patient interviews, provides crucial insights into the patient's health history, perception patterns, and lifestyle habits, all contributing significantly to GI health.
Health Perception Patterns
Health perception patterns offer valuable insights into a patient's lifestyle habits and how they may impact their GI health. These patterns include:
455
Binge Eating Disorders01:23

Binge Eating Disorders

423
Binge eating disorder is a significant mental health condition characterized by recurrent episodes of excessive food consumption within a short period, accompanied by a perceived loss of control over eating behavior. Unlike occasional overeating, binge eating disorder is marked by distressing emotions such as guilt, shame, and anxiety following binge episodes. The disorder affects individuals across different ages and backgrounds, with profound implications for physical and psychological...
423
Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation01:30

Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation

732
Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
732
Assessment of the Gastrointestinal System I: Subjective Data01:17

Assessment of the Gastrointestinal System I: Subjective Data

625
Assessing the gastrointestinal (GI) system is a complex process that begins with collecting subjective data. This data, collected through patient interviews, provides crucial insights into the patient's health history, perception patterns, and lifestyle habits, all contributing significantly to GI health.
Health History
The initial step in assessing the GI system is obtaining a comprehensive health history. This includes inquiring about the patient's history or presence of problems...
625

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of repetitive transcranial magnetic stimulation on cognition through sleep slow-wave activity in older adults.

Journal of neuroengineering and rehabilitation·2026
Same author

Expert Clinical Consensus on Body Surface Gastric Mapping Phenotypes for Gastroduodenal Disorders: 'Auckland Classification' v1.0.

Neurogastroenterology and motility·2026
Same author

From polythetic chaos to pragmatic psychiatry: Commentary on Fisher (2026).

Journal of psychopathology and clinical science·2026
Same author

Targeting cortico-striatal-amygdalar networks via theta-band frontoparietal synchronization in opioid use disorder: a randomized tACS-fMRI Trial.

Molecular psychiatry·2026
Same author

Prediction of cognitive performance by demographics, sleep, and brain morphometry: machine learning findings from ENIGMA-Sleep Working Group.

Research square·2026
Same author

Gastrointestinal Interoception and Relapse in Anorexia Nervosa.

JAMA psychiatry·2026
Same journal

Predicting Chemotherapy Response from Staging Laparoscopy Images.

medRxiv : the preprint server for health sciences·2026
Same journal

Development and External Validation of a Machine Learning Model for 10-Year Ischemic Stroke Risk Prediction in Diverse Populations.

medRxiv : the preprint server for health sciences·2026
Same journal

MCH-Guard: Multimodal Machine Learning Framework for Risk Stratification of Cerebral Microhemorrhage Risk in the Alzheimer's Disease Neuroimaging Initiative.

medRxiv : the preprint server for health sciences·2026
Same journal

Genetic and maternal environmental contributions to estimated fetal weight at 20 weeks gestation compared with birthweight.

medRxiv : the preprint server for health sciences·2026
Same journal

Better immediate declarative memory is associated with forgetting during locomotor adaptation in chronic stroke and in older adults.

medRxiv : the preprint server for health sciences·2026
Same journal

An empirical Bayes framework for burden and dispersion association tests helps prioritize rare variants associated with Alzheimer's disease.

medRxiv : the preprint server for health sciences·2026
See all related articles

Related Experiment Video

Updated: Jan 16, 2026

Control of Eating Behavior Using a Novel Feedback System
04:48

Control of Eating Behavior Using a Novel Feedback System

Published on: May 8, 2018

11.5K

Altered Gastrointestinal Interoception in Anorexia Nervosa Predicts Relapse.

Charles Verdonk1,2,3, Keller Mink1, Emily Choquette1

  • 1Laureate Institute for Brain Research, Tulsa, Oklahoma, United States.

Medrxiv : the Preprint Server for Health Sciences
|September 26, 2025
PubMed
Summary
This summary is machine-generated.

Anorexia nervosa (AN) patients have impaired gut sensation processing, leading to relapse. New objective biomarkers from a vibrating capsule test can predict recovery and symptom severity.

More Related Videos

Assessing Activity-based Anorexia in Mice
08:26

Assessing Activity-based Anorexia in Mice

Published on: May 14, 2018

13.0K
Using the Activity-based Anorexia Rodent Model to Study the Neurobiological Basis of Anorexia Nervosa
07:46

Using the Activity-based Anorexia Rodent Model to Study the Neurobiological Basis of Anorexia Nervosa

Published on: October 22, 2015

15.0K

Related Experiment Videos

Last Updated: Jan 16, 2026

Control of Eating Behavior Using a Novel Feedback System
04:48

Control of Eating Behavior Using a Novel Feedback System

Published on: May 8, 2018

11.5K
Assessing Activity-based Anorexia in Mice
08:26

Assessing Activity-based Anorexia in Mice

Published on: May 14, 2018

13.0K
Using the Activity-based Anorexia Rodent Model to Study the Neurobiological Basis of Anorexia Nervosa
07:46

Using the Activity-based Anorexia Rodent Model to Study the Neurobiological Basis of Anorexia Nervosa

Published on: October 22, 2015

15.0K

Area of Science:

  • Neuroscience
  • Gastroenterology
  • Psychiatry

Background:

  • Anorexia nervosa (AN) is a severe psychiatric disorder with high relapse rates.
  • Current recovery tracking lacks objective biomarkers.
  • Gastrointestinal interoception is disrupted in AN, but not clinically assessed.

Purpose of the Study:

  • To investigate gastrointestinal interoception deficits in AN.
  • To identify objective biomarkers for AN relapse and symptom severity.
  • To explore computational mechanisms underlying interoceptive dysfunction in AN.

Main Methods:

  • Single-blind, randomized-crossover study with 62 AN patients and 57 controls.
  • Ingestible vibrating capsule task to assess gastrointestinal detection.
  • Simultaneous recording of behavioral, EEG, and physiological signals.
  • Computational modeling of interoceptive processing.

Main Results:

  • AN participants exhibited reduced perceptual accuracy and higher miss-rates in gut sensation detection.
  • Computational models showed stronger prior beliefs against gut sensations and diminished interoceptive precision in AN.
  • Capsule stimulation induced greater hunger increases in AN patients.
  • Predictors of relapse included initial priors, response bias, and stomach unpleasantness.
  • Miss-rate and precision shifts predicted symptom severity.

Conclusions:

  • Mechanistic disruptions in gastrointestinal interoception are identified in AN.
  • These disruptions serve as predictive biomarkers for relapse and symptom severity.
  • Scalable biomarkers can personalize AN treatment and prevent recurrence.