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Highly selective 1,4-NADH regeneration via hydrogenated NAD+ analogs using a Pt/SiO2 catalyst with low pressure
Makoto Hirano1, Wataru Onodera2, Masazumi Tamura2,3
1Graduate School of Science, Osaka Metropolitan University, 3-3-138 Sugimoto, Sumiyoshi-ku, Osaka, 558-8585, Japan. ss23240i@st.omu.ac.jp.
Abstract:
The hydrogenation of nicotinamide analogs using a Pt/SiO2 catalyst, followed by hydride transfer to NAD+, results in the highly selective regeneration of 1,4-NADH. N-Methyl nicotinamide exhibits the highest reactivity, achieving 98% selectivity at 20 °C under 1 atm H2. This strategy provides a practical and sustainable pathway for 1,4-NADH regeneration.
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